Studies on the comparative efficacy of different analogues of prostaglandin F2 alpha for estrus synchronization in cows

ALISHA; PRAVESH  KUMAR; AKSHAY  SHARMA; PANKAJ  SOOD; ANKIT  AHUJA; AMIT  SHARMA; PURURAVA  SHARMA; VARUN  SHANKHYAN

doi:10.56093/ijans.v96i6.161110

Authors

ALISHA Dr. GC Negi College of Veterinary and Animal Sciences, CSKHPKV, Palampur, 176 061 Himachal Pradesh, India
PRAVESH KUMAR Dr. GC Negi College of Veterinary and Animal Sciences, CSKHPKV, Palampur, 176 061 Himachal Pradesh, India
AKSHAY SHARMA Dr. GC Negi College of Veterinary and Animal Sciences, CSKHPKV, Palampur, 176 061 Himachal Pradesh, India
PANKAJ SOOD Dr. GC Negi College of Veterinary and Animal Sciences, CSKHPKV, Palampur, 176 061 Himachal Pradesh, India
ANKIT AHUJA Dr. GC Negi College of Veterinary and Animal Sciences, CSKHPKV, Palampur, 176 061 Himachal Pradesh, India
AMIT SHARMA Dr. GC Negi College of Veterinary and Animal Sciences, CSKHPKV, Palampur, 176 061 Himachal Pradesh, India
PURURAVA SHARMA Dr. GC Negi College of Veterinary and Animal Sciences, CSKHPKV, Palampur, 176 061 Himachal Pradesh, India
VARUN SHANKHYAN Dr. GC Negi College of Veterinary and Animal Sciences, CSKHPKV, Palampur, 176 061 Himachal Pradesh, India

https://doi.org/10.56093/ijans.v96i6.161110

Keywords:

Cloprostenol, Cyclic cows, D-cloprostenol, Dinoprost, Estrus induction, PGF2α analogues

Abstract

In cattle reproduction, luteolysis is a crucial event that regulates the estrous cycle. Both endogenous and exogenous PGF2α induce luteolysis in most cows with a mature corpus luteum (CL). A study was conducted on 30 normal cycling cows (divided into three groups of 10 animals each) to evaluate the efficacy of cloprostenol, D-cloprostenol, and dinoprost tromethamine when administered intramuscularly. The investigation was carried out in nearby villages at farmers' doorstep from February 2023 to June 2024. In these groups, prostaglandins were administered eight days post-ovulation, and thereafter transrectal ultrasonography (TRUS) was done to assess the diameter and functionality of the CL using color Doppler. Ovarian examinations to monitor luteolysis and subsequent estrus were performed every 24 hours until ovulation. Cloprostenol resulted in a greater non-significant percentage reduction in CL size compared to D-cloprostenol and dinoprost. A significantly (P<0.10) larger final increase in follicle size was observed with cloprostenol compared to D-cloprostenol and dinoprost. The most substantial decrease in progesterone (P₄) concentration and percentage was observed with D-cloprostenol, followed by cloprostenol and dinoprost. Progesterone levels in all groups reached basal concentrations after 96 hours. Among the treatments, cloprostenol achieved the highest conception rate (50%), followed by D-cloprostenol (40%), with the lowest conception rate recorded for dinoprost (30%).

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