Electrolyte, blood gas and acid-base imbalance in canine chronic renal disease in dogs
271 / 226
Keywords:
Chronic kidney disease, Acid-base, ElectrolytesAbstract
Chronic kidney disease (CKD) in dogs is a progressive and often irreversible condition where the kidneys gradually lose their ability to filter waste, regulate fluid balance and maintain essential electrolyte levels. Acid-base disturbances are commonly identified in critically ill veterinary patients. So, the present investigation was aimed to study blood gas, acid base and electrolyte alteration in canine chronic kidney disease. Study was conducted on 20 dogs suffering from stage IV chronic kidney disease out of which 10 cases were found to be positive for haemoprotozoan infection through microscopic examination or rapid diagnostic kits. Haematologically mean values of TEC, PCV and Platelets were significantly reduced. Biochemically the mean values of Creatinine, SGPT and SGOT were significantly increased. Mean values of HCO3, pCO2, BE and BB were significantly decreased as compared to healthy dogs on venous blood gas and acid-base analysis. Electrolyte and mineral estimation revealed significant decrease in the values of sodium, chloride, calcium and magnesium whereas phosphorus were increased. The assessment of blood gas, acid-base balance, electrolyte levels and timely presentation of clinical cases played a crucial role in managing canine chronic kidney disease.
Downloads
References
Alvarez, L. and Whittemore, J. 2009. Liver enzyme elevations in dogs: physiology and pathophysiology. Compend. Contin. Educ. Vet., 31(9): 408–410, 412–413.
Crivellenti, S., Crivellenti, L.Z., Gilor, C. 2023. Anaemia in canine chronic kidney disease is multifactorial and associated with decreased erythroid precursor cells, gastrointestinal bleeding, and systemic inflammation. Am. J. Vet. Res., 84(10): 1–6.
Bradea, A., Codreanu, M., Vlagioiu, C. and Simion, V. 2013. Hematologic aspects in chronic kidney disease (CKD) in dogs. Bull. Univ. Agric. Sci. Vet. Med. Cluj-Napoca Vet. Med., 70(2): 191–194.
Buduk, S.Y., Sinha, R., Bera, A.K. and Suresh, R.V. 2019. Electrolyte and acid-base alterations in dogs with renal dysfunction. Int. J. Sci. Environ. Technol. 8(1): 10–15.
Carrero, J.J., Johansen, K.L., Lindholm, B., Stenvinkel, P., Cuppari, L. and Avesani, C.M. 2016. Screening for muscle wasting and dysfunction in patients with chronic kidney disease. Kidney Int., 90(1): 53–66.
Devipriya, K., Lavanya, C., Selvaraj, P. and Napolean, R.E. 2018. Early diagnosis of renal insufficiency in dogs with haemato-biochemical findings. J. Entomol. Zool. Stud,. 6(5): 703–705.
Eashwar, A., Ashwinii, R., Sagare, R., Krishna, C. J., Senthil, N. R. and Tejashree, M. 2024. Haemato-biochemical alterations in dogs suffering from chronic renal failure. Int. J. Vet. Sci. Anim. Husbandry, SP-9(4): 01–03.
Kandula, S. and Karlapudi, S. K. 2015. Prevalence of renal disorders in dogs – a clinical study. Int. J. Agric. Sci. Vet. Med., 2(3): 146–148.
Koenhemsi, L. and Gonul, R. 2019. Determination of renal blood flow with Doppler ultrasound and the hypertension prevalence and acid-base level in dogs with chronic renal failure. J. Istanbul Vet. Sci., 3: 6–12.
Kumar, C., Kamran, A. and Isloor, S. 2020. Clinical signs observed in different stages of chronic kidney disease in dogs. Int. J. Livest. Res,. 10: 249–252.
Lefebvre, H. 2011. Renal function testing. In: Nephrology and Urology of Small Animals, Bartges, J. and Polzin, D. (eds.) Wiley-Blackwell, Ames, IA, USA, pp. 91–96.
Lippi, I., et al. 2023. Serum bicarbonate deficiency in dogs with acute and chronic kidney disease. Vet. Sci., 10(5): 363.
Nakang, H., Changkija, B., Baishya, B.C., Mahato, G., Devi, P. and Kalita, M. 2019. Clinical and haemato-biochemical alterations in canine renal dysfunction. International Journal of Livestock Research, 9(8): 164–171.
Prowle, J.R., Echeverri, J.E., Ligabo, E.V., Ronco, C. and Bellomo, R. 2010. Fluid balance and acute kidney injury. Nat. Rev. Nephrol., 6(2): 107–115.
Puri, D., Dua, K., Sood, N.K., Randhawa, S. and Dhaliwal, P.S. 2015. Study of renal dysfunctions in geriatric dogs. Vet. Pract., 16(1): 44–46.
Sakaguchi, Y. (2022). The emerging role of magnesium in CKD. Clinical and Experimental Nephrology, 26(5): 379–384.
Schenck, P.A. and Chew, D.J. 2005. Calcium, phosphorus, parathyroid hormone, and renal secondary hyperparathyroidism. Am. J. Vet. Res., 66(8): 1330–1336.
Sharma, A., Ahuja, A., Srivastava, M. and Kachhawa, J.P. 2015. Haemato-biochemical changes in dogs suffering from chronic renal failure. Indian J. Canine Pract., 7(2): 102–107.
Sonu, A.K., Charaya, G., Bangar, Y., Agnihotri, D. and Kumar, T. (2019). Haemato-biochemical alterations in dogs suffering from chronic renal failure. Indian J. Vet. Med., 39(1): 31–35.
Sumit, Goel, P., Kumar, P., Gulia, D., Jhambh, R., Sindhu, N. and Chaudhary, R. N. 2018. Haematobiochemical and serum electrolytes alteration in dogs with chronic kidney disease. Pharma Innov. J., 7(11): 302–306.
Tvedten, H. and Willard, M.D. 2016. Laboratory diagnosis of renal disorders. In: Small Animal Clinical Diagnosis by Laboratory Methods. V edn., Elsevier.