Oxidative and histopathological damage in liver and plasma of rats after SO2 inhalation: SO2 inhalation damage in liver and plasma of rats

Dr. Prerna; Dr. Neena Singla

doi:10.59512/aaz.2023.62.4.5

Authors

Dr. Prerna Punjab Agricultural University, Ludhiana
Dr. Neena Singla Punjab Agricultural University, Ludhiana

https://doi.org/10.59512/aaz.2023.62.4.5

Keywords:

Sulphur dioxide (SO2), rats, liver, histopathology, oxidative damage, air pollutant

Abstract

Effect of different concentrations of SO2 on
antioxidant enzymes and histopathology was investigated
in liver and plasma of rats of both the sexes under natural
and experimental conditions. Naturally exposed, house rat,
Rattus rattus (Group I) were collected from urban residential
areas at Ludhiana, India and acclimatized for one month
in the laboratory. Laboratory bred house rats were divided
into four groups. Each group was further subdivided into
two subgroups having six male and six female rats. Group II
(control rats) were exposed to filtered air in one m3 exposure
chamber for five hours day-1 for 28 days; Group III, Group
IV and Group V were exposed to 5, 10 and 15 ppm of SO2
respectively. All the three concentrations of SO2 showed
significant increase in lipid peroxidation (LPO) levels
followed by significant decrease in the activities of superoxide
dismutase (SOD), catalase (CAT) and glutathione reductase
(GR) and non-significant decrease in glutathione peroxidase
(GPx) and glutathione (GSH) levels in plasma and liver of
rats of both the sexes. The increase in LPO levels was more
significant at 15 ppm concentration as compared to other two
concentrations in all the organs. The results showed that SO2
is an oxidative damage causing agent to vital organs of rats.

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Author Biography

Dr. Neena Singla, Punjab Agricultural University, Ludhiana

Professor cum Head, Department of Zoology

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