Folate Analysis in Ancient Wheat Variety: A Comprehensive Review of Factors Impacting


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Authors

  • Nikita Purbia Maharana Pratap University of Agriculture and Technology, Udaipur, 313 001, India
  • Sumitra Meena Maharana Pratap University of Agriculture and Technology, Udaipur, 313 001, India
  • Sakshi R Yadav Maharana Pratap University of Agriculture and Technology, Udaipur, 313 001, India

https://doi.org/10.56093/aaz.v64i2.153736

Abstract

This comprehensive review explores the nutritional significance of ancient wheat varieties, including spelt, einkorn, emmer, and Khorasan wheat, focusing on their folate content. Wheat, a fundamental cereal grain, plays a crucial role in global diets. Despite claims about the high folic acid content in ancient wheat, there is limited research to substantiate these assertions. The review systematically compares folate levels in ancient wheat varieties, highlighting the scarcity of data in this domain. Factors influencing folate content, such as geographic and genetic variations, processing, milling, fermentation, germination, and storage, are extensively examined. The study emphasizes the potential health benefits of consuming folate-enriched ancient wheat, addressing deficiencies and offering practical strategies like crop fortification. Additionally, it discusses dietary recommendations for folate intake in India. The methodology section details challenges in folate quantification, utilizing microbiological assay and high-performance liquid chromatography. In conclusion, this review calls for a renewed focus on the exploration and validation of the nutritional profile of ancient wheat varieties, emphasizing their potential to contribute significantly to improved dietary folate intake and public health

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Author Biographies

  • Nikita Purbia, Maharana Pratap University of Agriculture and Technology, Udaipur, 313 001, India

    PG Student, Food Science and Nutrition Dept, College of Community and Applied Sciences, Maharana Pratap University of Agriculture and Technology, Udaipur, Rajasthan

  • Sumitra Meena, Maharana Pratap University of Agriculture and Technology, Udaipur, 313 001, India

    Assistant Professor, Food Science and Nutrition Dept, College of Community and Applied Sciences, Maharana Pratap University of Agriculture and Technology, Udaipur, Rajasthan

  • Sakshi R Yadav, Maharana Pratap University of Agriculture and Technology, Udaipur, 313 001, India

    PG Student, Food Science and Nutrition Dept, College of Community and Applied Sciences, Maharana Pratap University of Agriculture and Technology, Udaipur, Rajasthan

     

References

Arcot, J, Wootton, M., Alury, S., Chan, H., & Shrestha, A. K. (2002). Folate levels in twelve Australian Wheat and changes during processing inton bread. Food Australia , 54, 18–20.

Ashokkumar, K., Govindaraj, M., Karthikeyan, A., Shobhana, V. G., & Warkentin, T. D. (2020). Genomics-integrated breeding for carotenoids and folates in staple cereal grains to reduce malnutrition. Frontiers in Genetics, 11, 414. https://doi.org/10.3389/fgene.2020.00414

Bationo, F., Humblot, C., Songré-Ouattara, L. T., Hama-Ba, F., Le Merrer, M., Chapron, M., Kariluoto, S., & Hemery, Y. M. (2020). Total folate in West African cereal-based fermented foods: Bioaccessibility and influence of processing. Journal of Food Composition and Analysis, 85, 103309. https://doi.org/10.1016/j.jfca.2019.103309

Bordoni, A., Danesi, F., Di Nunzio, M., Taccari, A., & Valli, V. (2017). Ancient wheat and health: A legend or the reality? A review on KAMUT khorasan wheat. International Journal of Food Sciences and Nutrition, 68(3), 278–286. https://doi.org/10.1080/09637486.2016.1247434

Botto, L. D., Lisi, A., Robert-Gnansia, E., Erickson, J. D., Vollset, S. E., Mastroiacovo, P., Botting, B., Cocchi, G., De Vigan, C., De Walle, H., Feijoo, M., Irgens, L. M., McDonnell, B., Merlob, P., Ritvanen, A., Scarano, G., Siffel, C., Metneki, J., Stoll, C., … Goujard, J. (2005). International retrospective cohort study of neural tube defects in relation to folic acid recommendations: Are the recommendations working? BMJ, 330(7491), 571. https://doi.org/10.1136/bmj.38336.664352.82

Boz, H. (2021). Effect of processing on cereal folates. Journal of Cereal Science, 99, 103202. https://doi.org/10.1016/j.jcs.2021.103202

Crider, K. S., Yang, T. P., Berry, R. J., & Bailey, L. B. (2012). Folate and dna methylation: A review of molecular mechanisms and the evidence for folate’s role. Advances in Nutrition, 3(1), 21–38. https://doi.org/10.3945/an.111.000992

Ducker, G. S., & Rabinowitz, J. D. (2017). One-carbon metabolism in health and disease. Cell Metabolism, 25(1), 27–42. https://doi.org/10.1016/j.cmet.2016.08.009

Fenech, M., Noakes, M., Clifton, P., & Topping, D. (1999). Aleurone flour is a rich source of bioavailable folate in humans. The Journal of Nutrition, 129(6), 1114–1119. https://doi.org/10.1093/jn/129.6.1114

Fujita, A., Simsek, S., & Schwarz, P. B. (2020). Observations on the malting of ancient wheats: Einkorn, emmer and spelt. Fermentation, 6(4), 125. https://doi.org/10.3390/fermentation6040125

Gazzali, A. M., Lobry, M., Colombeau, L., Acherar, S., Azaïs, H., Mordon, S., Arnoux, P., Baros, F., Vanderesse, R., & Frochot, C. (2016). Stability of folic acid under several parameters. European Journal of Pharmaceutical Sciences, 93, 419–430. https://doi.org/10.1016/j.ejps.2016.08.045

Giambanelli, E., Ferioli, F., Koçaoglu, B., Jorjadze, M., Alexieva, I., Darbinyan, N., & D’Antuono, L. F. (2013). A comparative study of bioactive compounds in primitive wheat populations from Italy, Turkey, Georgia, Bulgaria and Armenia. Journal of the Science of Food and Agriculture, 93(14), 3490–3501. https://doi.org/10.1002/jsfa.6326

Giordano, D., Reyneri, A., & Blandino, M. (2016). Folate distribution in barley (hordeum vulgare l.), common wheat (triticum aestivum l.)and durum wheat p(triticum turgidum durum desf.)earled fractions. Journal of the Science of Food and Agriculture, 96(5), 1709–1715. https://doi.org/10.1002/jsfa.7276

Hefni, M. E., Schaller, F., & Witthöft, C. M. (2018). Betaine, choline and folate content in different cereal genotypes. Journal of Cereal Science, 80, 72–79. https://doi.org/10.1016/j.jcs.2018.01.013

Hefni, M., & Witthöft, C. M. (2012). Effect of germination and subsequent oven-drying on folate content in different wheat and rye cultivars. Journal of Cereal Science, 56(2), 374–378. https://doi.org/10.1016/j.jcs.2012.03.009

Hidalgo, A., & Brandolini, A. (2012). Lipoxygenase activity in wholemeal flours from Triticum monococcum, Triticum turgidum and Triticum aestivum. Food Chemistry, 131(4), 1499–1503. https://doi.org/10.1016/j.foodchem.2011.09.132

Jirillo, E., Carone, T., & Toffanin, R. (2017). Exploitation of old wheat properties for prevention of human disease. Natural Product Communications, 12(6), 1934578X1701200. https://doi.org/10.1177/1934578X1701200605

Jones, J. M., Peña, R. J., Korczak, R., & Braun, H. J. (2015). Cimmyt series on carbohydrates, wheat, grains, and health: Carbohydrates, grains, and wheat in nutrition and health: an overview. Part ii. Grain terminology and nutritional contributions. Cereal Foods World, 60(6), 260–271. https://doi.org/10.1094/CFW-60-6-0260

Kanmani, P., Satish Kumar, R., Yuvaraj, N., Paari, K. A., Pattukumar, V., & Arul, V. (2013). Probiotics and its functionally valuable products—A review. Critical Reviews in Food Science and Nutrition, 53(6), 641–658. https://doi.org/10.1080/10408398.2011.553752

Kariluoto, S., Edelmann, M., & Piironen, V. (2010). Effects of environment and genotype on folate contents in wheat in the healthgrain diversity screen. Journal of Agricultural and Food Chemistry, 58(17), 9324–9331. https://doi.org/10.1021/jf100251j

Kariluoto, S., Liukkonen, K.-H., Myllymäki, O., Vahteristo, L., Kaukovirta-Norja, A., & Piironen, V. (2006). Effect of germination and thermal treatments on folates in rye. Journal of Agricultural and Food Chemistry, 54(25), 9522–9528. https://doi.org/10.1021/jf061734j

Katina, K., Liukkonen, K.-H., Kaukovirta-Norja, A., Adlercreutz, H., Heinonen, S.-M., Lampi, A.-M., Pihlava, J.-M., & Poutanen, K. (2007). Fermentation-induced changes in the nutritional value of native or germinated rye. Journal of Cereal Science, 46(3), 348–355. https://doi.org/10.1016/j.jcs.2007.07.006

Konings, E. J., Roomans, H. H., Dorant, E., Goldbohm, R. A., Saris, W. H., & Van Den Brandt, P. A. (2001). Folate intake of the Dutch population according to newly established liquid chromatography data for foods. The American Journal of Clinical Nutrition, 73(4), 765–776. https://doi.org/10.1093/ajcn/73.4.765

Laiño, J. E., Juarez Del Valle, M., Savoy De Giori, G., & LeBlanc, J. G. J. (2013). Development of a high folate concentration yogurt naturally bio-enriched using selected lactic acid bacteria. LWT - Food Science and Technology, 54(1), 1–5. https://doi.org/10.1016/j.lwt.2013.05.035

Liang, Q., Wang, K., Shariful, I., Ye, X., & Zhang, C. (2020). Folate content and retention in wheat grains and wheat-based foods: Effects of storage, processing, and cooking methods. Food Chemistry, 333, 127459. https://doi.org/10.1016/j.foodchem.2020.127459

Matsuoka, Y. (2011). Evolution of polyploid triticum wheats under cultivation: The role of domestication, natural hybridization and allopolyploid speciation in their diversification. Plant and Cell Physiology, 52(5), 750–764. https://doi.org/10.1093/pcp/pcr018

Morris, C. F. (2016). Evaluation of wheat-grain quality attributes. In Encyclopedia of Food Grains (pp. 251–256). Elsevier. https://doi.org/10.1016/B978-0-12-394437-5.00247-3

Moslehi-Jenabian, S., Lindegaard, L., & Jespersen, L. (2010). Beneficial effects of probiotic and food borne yeasts on human health. Nutrients, 2(4), 449–473. https://doi.org/10.3390/nu2040449

National institute of nutrition, india. (n.d.). Retrieved November 8, 2023, from https://www.nin.res.in/RDA_short_Report_2020.html

Obeid, R. (2013). The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Nutrients, 5(9), 3481–3495. https://doi.org/10.3390/nu5093481

Ohrvik, V. E., & Witthoft, C. M. (2011). Human folate bioavailability. Nutrients, 3(4), 475–490. https://doi.org/10.3390/nu3040475

Paesani, C., Moiraghi, M., Sciarini, L., & Pérez, G. T. (2021). Whole-flours from hard and soft wheat genotypes: Study of the ability of prediction test to estimate whole flour end-use. Journal of Food Science and Technology, 58(4), 1462–1469. https://doi.org/10.1007/s13197-020-04658-1

Paigambari ancient wheat. (n.d.). Retrieved November 6, 2023, from https://www.paigambari.com

Piironen, V., Edelmann, M., Kariluoto, S., & Bedő, Z. (2008). Folate in wheat genotypes in the healthgrain diversity screen. Journal of Agricultural and Food Chemistry, 56(21), 9726–9731. https://doi.org/10.1021/jf801066j

Production of wheat worldwide 2022/2023. (n.d.). Statista. Retrieved November 5, 2023, from https://www.statista.com/statistics/267268/production-of-wheat-worldwide-since-1990/

Rakszegi, M., Boros, D., Kuti, C., Láng, L., Bedo ̋, Z., & Shewry, P. R. (2008). Composition and end-use quality of 150 wheat lines selected for the healthgrain diversity screen. Journal of Agricultural and Food Chemistry, 56(21), 9750–9757. https://doi.org/10.1021/jf8009359

Ratajczak, K., Sulewska, H., Grażyna, S., & Matysik, P. (2020). Agronomic traits and grain quality of selected spelt wheat varieties versus common wheat. Journal of Crop Improvement, 34(5), 654–675. https://doi.org/10.1080/15427528.2020.1761921

Riaz, B., Liang, Q., Wan, X., Wang, K., Zhang, C., & Ye, X. (2019). Folate content analysis of wheat cultivars developed in the North China Plain. Food Chemistry, 289, 377–383. https://doi.org/10.1016/j.foodchem.2019.03.028

Salvucci, E., LeBlanc, J. G., & Pérez, G. (2016). Technological properties of Lactic acid bacteria isolated from raw cereal material. LWT, 70, 185–191. https://doi.org/10.1016/j.lwt.2016.02.043

Saubade, F., Hemery, Y. M., Guyot, J.-P., & Humblot, C. (2017). Lactic acid fermentation as a tool for increasing the folate content of foods. Critical Reviews in Food Science and Nutrition, 57(18), 3894–3910. https://doi.org/10.1080/10408398.2016.1192986

Shewry, P. R. (2018). Do ancient types of wheat have health benefits compared with modern bread wheat? Journal of Cereal Science, 79, 469–476. https://doi.org/10.1016/j.jcs.2017.11.010

Shewry, P. R., & Hey, S. (2015). Do “ancient” wheat species differ from modern bread wheat in their contents of bioactive components? Journal of Cereal Science, 65, 236–243. https://doi.org/10.1016/j.jcs.2015.07.014

Tamene, A., Kariluoto, S., Baye, K., & Humblot, C. (2019). Quantification of folate in the main steps of traditional processing of tef injera, a cereal based fermented staple food. Journal of Cereal Science, 87, 225–230. https://doi.org/10.1016/j.jcs.2019.04.005

Tran, K. D., Konvalina, P., Capouchova, I., Janovska, D., Lacko-Bartosova, M., Kopecky, M., & Tran, P. X. T. (2020). Comparative study on protein quality and rheological behavior of different wheat species. Agronomy, 10(11), 1763. https://doi.org/10.3390/agronomy10111763

Upadhyaya, P., Tyagi, K., Sarma, S., Tamboli, V., Sreelakshmi, Y., & Sharma, R. (2017). Natural variation in folate levels among tomato (Solanum lycopersicum) accessions. Food Chemistry, 217, 610–619. https://doi.org/10.1016/j.foodchem.2016.09.031

Zheng, J., Wang, X., Wu, B., Qiao, L., Zhao, J., Pourkheirandish, M., Wang, J., & Zheng, X. (2022). Folate (Vitamin b9) content analysis in bread wheat (Triticum aestivum L.). Frontiers in Nutrition, 9, 933358. https://doi.org/10.3389/fnut.2022.933358

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Submitted

12-07-2024

Published

27-06-2025

How to Cite

Purbia, N., Meena, D. S., & Yadav, . S. R. (2025). Folate Analysis in Ancient Wheat Variety: A Comprehensive Review of Factors Impacting. Annals of Arid Zone, 64(2), 221-228. https://doi.org/10.56093/aaz.v64i2.153736
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