Wound healing potential of a gel formulation of porcine cholecyst extracellular matrix in a rat full-thickness excision model

Abstract

Collagen-rich extracellular matrices (ECMs) recovered from mammalian organs and tissue have found clinical uses in several formats like thin sheets, powder, ointments, gels, etc.; either as a standalone tissue engineering scaffold or in combination with other biomaterials and pharmaceuticals for many regenerative medical applications. Out of these, gel formulations of ‘advanced wound care products’ made of animal-derived ECMs have high utility because of structural adaptability, biocompatibility, and tunable physicochemical properties. This study demostrated the wound healing potential of a porcine cholecystic extracellular matrix gel formulation in rat full-thickness skin-excision wound model by gross and histomorphological studies.