Serological response to anti-rabies vaccination in animals: Failure to achieve protective antibody level


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Authors

  • MADHAV MUGALE
  • B S SANDHU
  • T S RAI
  • C K SINGH
  • N K SOOD

Keywords:

tibody, Anti rabies vaccine, Dogs, ELISA, Serosurveillance, Titre

Abstract

The present study was conducted to elucidate the serological response in 183 rabies suspected cases of small and
large animals presented Veterinary Clinical Complex from July 2010 to June 2011. Immune status was assessed by
ELISA. Out of 183 cases, 180 were dogs and 3 large animals. In vaccinated dogs, rabies virus specific antibodies
(0.5IU/μl) were detected in 70.55% (115/163) cases. Whereas 29.44% vaccinated dogs did not reveal protective rabies titre. None of the unvaccinated dogs and large animals showed protective rabies specific antibody titre. The antibody
level was directly proportional to the number of vaccine shots. Vaccination in dewormed animals revealed better protection
and antibody titre (8.878 IU/μl) than non-dewormed animals (4.01 IU/μl). However, no significant difference in the
rabies antibody titre among the sexes was observed.

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Author Biographies

  • MADHAV MUGALE
    M.V.Sc. Student, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab 141 004 India

  • B S SANDHU
    Associate Professor, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab 141 004 India

  • T S RAI
    Professor Department of Veterinary Microbiology, College of Veterinary Sciences
  • C K SINGH
    Senior Veterinary Pathologist, Department of Veterinary Microbiology, College of Veterinary Sciences

  • N K SOOD
    Senior Veterinary Pathologist cum Head,
    Department of Veterinary Pathology; Department of Veterinary Microbiology, College of Veterinary Sciences

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Issue

Vol. 83 No. 3 (2013)

Section

Articles

License

The copyright of the articles published in The Indian Journal of Animal Sciences is vested with the Indian Council of Agricultural Research, which reserves the right to enter into any agreement with any organization in India or abroad, for reprography, photocopying, storage and dissemination of information. The Council has no objection to using the material, provided the information is not being utilized for commercial purposes and wherever the information is being used, proper credit is given to ICAR.

How to Cite

MUGALE, M., SANDHU, B. S., RAI, T. S., SINGH, C. K., & SOOD, N. K. (2013). Serological response to anti-rabies vaccination in animals: Failure to achieve protective antibody level. The Indian Journal of Animal Sciences, 83(3). http://epubs.icar.org.in/index.php/IJAnS/article/view/28074