Therapeutic efficacy of isometamidium hydrochloride and diminazene diaceturate in treatment of trypanosomiasis in horses

Rajinder Kumar Bhardwaj; Sudhir Kumar; Himani Sharma

doi:10.56093/ijvm.v44i2.158070

Authors

Rajinder Kumar Bhardwaj Professor, Division of Veterinary MedicineF.V.Sc & A.H-R.S.Pura, SKUAST-Jammu 181102
Dr. Sudhir Kumar
Dr. Himani Sharma

https://doi.org/10.56093/ijvm.v44i2.158070

Keywords:

Equine, Trypanosomiasis, GSTB, Isometamidium hydrochloride, Diminazene diaceturate

Abstract

Twelve equines found positive for Trypanosoma evansi in Giemsa-stained thin blood smears (GSTBS) were divided in two groups (n=6) each. Group-I was treated with single injection of isometamidium hydrochloride @ 0.5mg/kg b.wt I/M and Group-II treated with single injection of diminazene diaceturate@ 5mg/kg b.wt I/M. Giemsa-stained thin blood smears examination could detect T. evansi in 2 horses treated with diminazene diaceturate on 3^rd day of treatment while all six horses of isometamidium hydrochloride treated group were found negative for T. evansi. Horses’ positive for T. evansi on 3^rd day were found negative after another dose of diminazene diaceturate. Increase in the value of Hb and TEC was observed on 7^th day post treatment in isometamidium hydrochloride than diminazene diaceturate. Decrease in the value of TPP was observed on 7^th day post treatment in isometamidium hydrochloride treated equines as compared to diminazene diaceturate. Aspartate amino transferase, ALP and GGT also showed significant decrease in isometamidium hydrochloride treated equines as compared to diminazene diaceturate on 3^rd and 7^th day post treatment. It can be concluded that isometamidium hydrochloride has higher therapeutic efficacy in clearing the Trypanosoma as compared to diminazene diaceturate.

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Author Biographies

Rajinder Kumar Bhardwaj, Professor, Division of Veterinary MedicineF.V.Sc & A.H-R.S.Pura, SKUAST-Jammu 181102

PROFESSOR, F.V.Sc & A.H-R.S.Pura SKUAST-Jammu 181102 India
Dr. Sudhir Kumar

Professor, Division of Veterinary Gynecology and Obstetrics F.V. Sc& A.H- R. S. Pura, SKUAST-Jammu, 181102, J&K
Dr. Himani Sharma

³PG , Division of Veterinary Medicine, F.V. Sc& A.H-R.S.Pura, SKUAST-Jammu, 181102, J&K

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