Comparative evaluation of aqueous leaf extract and dried latex powder of Carica papaya Linn. for their antidiabetic and antihyperlipidemic activities  in Wistar rats

Renuka Naidu Guntireddi; Chaitanya Kumar Thota Venkata; Eswara Prasad Pagadala; Adilaxmamma K; Sujatha K; Padmaja K

doi:10.56093/ijvm.v45i1.164122

Authors

G Renukanaidu College of Veterinary Science, Sri Venkateswara Veterinary University, Tirupati-517502, Andhrapradesh, India
Chaitanya Kumar Thota Venkata Department of Veterinary Biochemistry, College of Veterinary Science, Tirupati-517502
P Eswara Prasad College of Veterinary Science, Sri Venkateswara Veterinary University, Tirupati-517502, Andhrapradesh, India
K Adilaxmamma Department of Veterinary Pharmacology and Toxicology College of Veterinary Science, Tirupati-517502,
K Sujatha Department of Veterinary Pathology College of Veterinary Science, Tirupati-517502
K Padmaja Department of Veterinary Biochemistry College of Veterinary Science, Tirupati-517502

https://doi.org/10.56093/ijvm.v45i1.164122

Keywords:

Carica papaya, Antdiabetic property, Antihyperlipidemic effect, Aqueous leaf extract, Dried latex powder, Histopathlogy

Abstract

The present study was undertaken to evaluate and compare the effect of dried latex powder (DLPCP) and aqueous leaf extract (ALECP) of Carica papaya Linn. in streptozotocin induced diabetic rat model for a period of 21 days for their antidiabetic and antihyperlipidemic properties. A total of 32 male Wistar rats, divided into four groups with eight animals in each group. The groups include normal control (Group-I), diabetic control (Group-II), diabetic rats treated with DLPCP @ 400mg/Kg b.wt (Group-III) and diabetic rats treated with ALECP @ 400 mg/Kg b.wt (Group-IV). Serum was collected on 0^th , 4^th, 14^th and 21^st days from all the experimental rats for serum biochemical analysis. On 21^st day, the animals were sacrificed for histopathological examination of pancreas and liver. ALECP treatment group has shown antihyperglycemic activity as early as the 4^th day (327.7 + 18.65) and hepatoprotective activity on the 4^th day (252.9 + 4.6, 155.3 + 4.8), whereas, DLPCP treatment group has shown the similar affect on 21^st day (311.7 + 28.83) and on 14^th day (228.8 + 10.6, 179.8 + 0.9) of experiment respectively. Antihyperlipidemic affect was exhibited by both the treatment groups with reduced triglycerides, total cholesterol, LDL, VLDL and increased HDL levels, when compared to diabetic control groups. Histopathological examination has endorsed the biochemical findings. ALECP treatment when compared to DLPCP treatment has shown a better antidiabetic activity on the early days of experiment by ameliorating its associated affects. The present study indicate that ALECP acts as an alternative remedy for diabetes milletus.

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