Doxorubicin and cyclophosphamide chemotherapy, with or without surgical excision, for management of canine mammary tumours
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Authors
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Atul Yadav
Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan, Mathura-281001 (Uttar Pradesh)
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S. Purohit
Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan, Mathura-281001 (Uttar Pradesh)
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Chetan Sharma
Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan, Mathura-281001 (Uttar Pradesh)
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Ravi Tadagani
Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan, Mathura-281001 (Uttar Pradesh)
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Prabha Sharma
Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan, Mathura-281001 (Uttar Pradesh)
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Neeraj Kumar Gangwar
Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan, Mathura-281001 (Uttar Pradesh)
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R.P. Pandey
Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan, Mathura-281001 (Uttar Pradesh)
Keywords:
Canine mammary tumour, Chemotherapy, Cyclophosphamide, DoxorubicinAbstract
The present study was carried in 18 canine mammary tumour cases. The dogs were divided into three groups viz., C, A, and S, as per the treatment given. The animals of group S were treated with surgery alone (simple mastectomy, enblock dissection and lumpectomy); in group A, the animals were treated with surgery and adjuvant chemotherapy with a combination of doxorubicin (25 mg/m2 i.v.) and cyclophosphamide (30 mg/m2 ), given at 10 days interval for three times; and group C animals were treated with chemotherapy alone. Lateral thoracic radiography was performed to evaluate the distant pulmonary metastasis. Ultrasonography was done in all the cases to determine the echogenicity of tumour mass. Histopathological evaluation revealed majority of the tumours to be malignant. Combination of doxorubicin and cyclophosphamide was found to be effective as an adjuvant therapy in the treatment of mammary tumours, and this combination increased the longevity and survival of animals.
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