Therapeutic management of appendicular osteoarthritis in dogs using platelet rich plasma (PRP) and pentosan polysulphate sodium
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Authors
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Nitesh Suryavanshi
Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)
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Randhir Singh
Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)
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Shobha Jawre
Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)
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Yamini Verma
Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)
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Rakesh Kumar Barhaiya
Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)
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Apoorva Mishra
Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)
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Babita Das
Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)
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Apra Shahi
Nanaji Deshmukh Veterinary Science University, Jabalpur- 482 001 (Madhya Pradesh)
Keywords:
Dog, Osteoarthritis, Pentosan polysulfate sodium, Platelet rich plasmaAbstract
The present study was conducted on 12 dogs suffering from appendicular joint osteoarthritis (OA) presented at Veterinary Clinical Complex, Jabalpur during the study period of six months. The dogs were equally distributed into three treatment groups. In group I, the dogs were treated with inj. carprofen 4 mg/kg body wt, s.c. for 5 days and tab. glucosamine hydrochloride 500 mg, chondroitin sulphate 400 mg, manganese sulphate 5 mg, Boswellia serrata 50 mg, Withania somnifera 50 mg, Vitamin C 12.5 mg orally for 30 days. The dogs of group II were treated as in group I with addition of an intra-articular injection of 1 mL platelet-rich plasma (PRP) on days 0, 7, 14, 28 and 45. The dogs of group III were treated as in group I with addition of an intraarticular injection of 1 mL PRP and pentosan polysulfate sodium 3 mg/kg body wt, s.c. on days 0, 7, 14, 28 and 45. The results indicated that both the treatment regimens (group II and III) were equally effective in reducing osteoarthritic pain; however, significant (P<0.05) decrease in lameness and pain bearing scores were earlier in group III as compared to group II.
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