Clinical adaptation of tiletamine-zolazepam for conducting different diagnostic and surgical procedures in dogs

Abstract

The objective of the study was to standardize the dose of tiletamine-zolazepam (Zoletil - 50®) in dogs followed by assessing the clinical adaptability of the standardized dose for various surgical manipulations. Twelve dogs were used in the study, among them 4 dogs were used to standardize the dose of tiletamine-zolazepam. The pilot doses of 3.3 mg/kg, 5 mg/kg, 6.6 mg/kg and 7 mg/kg body weight was administered intramuscularly up to satisfactory muscle relaxation with easy intubation. Out of which the dose of 7 mg/kg resulted in abolition of laryngeal reflex along with easy intubation. Thus, it was considered as standard dose and was further assessed for its adaptability in eight clinical cases. All the parameters were within the normal physiological range except for hypertension throughout the study period. In conclusion, tiletamine-zolazepam at the dose of 7 mg/kg body weight in dogs provided surgical restraint for 39.37±2.77 min without any adverse reactions with good recovery.