Effect of treatment on oxidative and nitrosative stress markers in calves with septic arthritis
71 / 47
Authors
-
Vandana
ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India, 243122
-
Ankit Dahiya
ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India, 243122
-
K. Mahendran
ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India, 243122
-
S. Dey
ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India, 243122
Keywords:
Arthritis, Ascorbic acid, Calves, Oxidative and nitrosative stress, SepsisAbstract
The current study was conducted at calf section of Cattle and buffalo Farm under the LPM Division of IVRI with the main objective to understand the oxidant-antioxidant imbalances along with changes in HR, RR, temperature, TLC, TP, LDH and their mitigation using ascorbic acid as an adjunct in calves affected with septic arthritis presented with the history of inappetence, fever, pain and local swelling at the joint. Overall incidence was reported to be 2.94%, which was highest in Vrindavani calves. To determine the oxidant-antioxidant imbalance, glutathione and lipid peroxides levels were measured, which were found to be elevated in diseased animals indicating the oxidative cell injury in arthritis. Treatment regimen adopted including administration of antibiotic and anti-inflammatory drugs, antiseptic dressing along with ascorbic acid (an antioxidant) brought earlier improvement showing that correction of oxidative stress during the course of therapy is essential for faster clinical recovery. Effect of therapy was also reflected in the composition of synovial fluid in calves receiving antioxidant as an adjunct therapy.
Downloads
References
Beltran, B., Mathur, A., Duchen, M.R., Erusalimsky, J.D. and Moncada, S. 2000. The effect of nitric oxide on cell respiration: a key to understanding its role in cell survival or death. Proc. Natl. Acad. Sci. USA. 26: 14602-14607.
Beydilli, Y. and Gökçe, H. 2019. Sepsisli neonatal buzaðýlarda bazý hematolojik ve biyokimyasal parametrelerin araþtýrýlmasý. Mehmet Akif Ersoy Univ Saðlýk Bilim Enst Derg. 7: 55-67.
Butt, T. 2002. Septic arthritis in horses: diagnosis and treatment. Large Anim. Vet. Rounds 2: 26-31.
Cheng, J.J., Ma, X.D., Ai, G.X., Yu, Q.X., Chen, X.Y., Yan, F., Li, Y.C., Xie, J.H., Su, Z.R. and Xie, Q.F. 2022. Palmatine protects against MSU-induced gouty arthritis via regulating the NF-êB/NLRP3 and Nrf2 pathways. Drug Des. Devel. Ther. 16: 2119- 2132.
Cimen, M.Y., Cimen, O.B., Kacmaz, M., Ozturk, H.S. and Yorgancioglu, R. 2000. Oxidant/antioxidant status of the erythrocytes from patients with rheumatoid arthritis. Clin. Rheumatol. 19: 275- 277.
Coles, E.H. 1980. Veterinary Clinical Pathology, 3rd edn. W.B. Saunders Co., Philadelphia. pp 348-354. Desrochers, A. 2004. Septic arthritis. In: Farm Animal Surgery, E.M. Fathman (Ed). Elsevier, Philadelphia. pp 330-336.
Desrochers, A. and Francoz, D. 2014. Clinical management of septic arthritis in cattle. Vet. Clin. North Am. Food Anim. Pract. 30: 177-203.
Dogan, E., Yanmaz, L.E., Okumus, Z., Kaya, M., Gokhan, M. and Cengiz, S. 2016. Radiographic, ultrasonographic and thermographic findings in neonatal calves with septic arthritis: 82 cases. Ataturk Univ. Vet. Bil. Derg. 11: 6-12.
El-barbary, A.M., Khalek, M.A.A., Elsalawy, A.M. and Hazaa, S.M. 2011. Assessment of lipid peroxidation and antioxidant status in rheumatoid arthritis and osteoarthritis patients. Egypt Rheumatol. 33: 179-185.
Ercan, N., Tuzcu, N., Baºbug, O., Tuzcu, M. and Alim, A. 2016. Diagnostic value of serum procalcitonin, neopterin, and gamma interferon in neonatal calves with septicemic colibacillosis. J. Vet. Diagn. Invest. 28: 180-183.
Francoz, D., Desrochers, A., Fecteau, G., Desautels, C., Latouche, J.S. and Fortin, M. 2005. Synovial fluid changes in induced infectious arthritis in calves. J. Vet. Intern. Med. 19: 336-343.
Gagea, M.I., Bateman, K.G., Shanahan, R.A., Van Dreumel, T. and McEwen, B.J. 2006. Naturally occurring Mycoplasma bovis-associated pneumonia and polyarthritis in feedlot beef calves. J. Vet. Diagn. Invest. 18: 29-40.
Haerdi-Landerer, M.C., Habermacher, J., Wenger, B., Suter, M.M. and Steiner, A. 2010. Slow-release antibiotics for treatment of septic arthritis in large animals. Vet. J. 184: 14-20.
Hardy, J. 2006. Etiology, diagnosis and treatment of septic arthritis, osteitis, and osteomyelitis in foals. Clin. Tech. Equine Pract. 5: 309-317.
Heppelmann, M., Kofler, J., Meyer, H., Rehage, J. and Starke, A. 2009. Advances in surgical treatment of septic arthritis of the distal interphalangeal joint in cattle: A review. Vet. J. 182: 162-175.
Jain, N.C. 1986. Schalm’s Veterinary Haematology, 4th edn. Lea & Febiger, Philadelphia, USA.
Meijer, M.C., Van Weeren, P.R. and Rijkenhuizen, A.B. 2000. Clinical experiences of treating septic arthritis in the equine by repeated joint lavage: a series of 39 cases. J. Vet. Med. A47: 351-365.
Orsini, J.A. 2002. Septic arthritis (Infectious arthritis). In: Large Animal Internal Medicine. B.P. Smith (Ed), 3rd edn. Mosby, Inc. St. Louis, Missouri. pp 1096- 1099.
Pas, M.L., Bokma, J., Lowie, T., Boyen, F. and Pardon, B. 2023. Sepsis and survival in critically ill calves: Risk factors and antimicrobial use. J. Vet. Int. Med. 37: 374-389.
Pesce, A.J. 1984. In: Enzymes in clinical chemistry: Theory, analysis and correlation. Kaplan, L.A. and Pesce, A.J. (Eds). C.V. Mosby, Toronto. pp 1079- 1130.
Pham, T.N., Rahman, P., Tobin, Y.M., Khraishi, M.M., Hamilton, S.F., Alderdice, C. and Richardson, V.J. 2003. Elevated serum nitric oxide levels in patients with inflammatory arthritis associated with co-expression of inducible nitric oxide synthase and protein kinase C-eta in peripheral blood monocyte-derived macrophages. J. Rheumatol. 30: 2529-2534.
Placer, Z.A., Cushman, L. and Johnson, B. 1966. Estimation of product of lipid peroxidation (malondialdehyde) in biochemical system. Anal. Biochem. 16: 359-364.
Prins, H.K. and Loos, J.A. 1969. Estimation of product of lipid peroxidation (Malonyldialdehyde) in biochemical system. Anal. Biochem. 34: 169-175.
Radostits, O.M., Gay, C.C., Blood, D.C. and Hinchcliff, K.W. 2007. Veterinary Medicine: A Textbook of the Diseases of Cattle, Sheep, Pigs, Goats and Horses. 10th edn. W.B. Saunders, London. pp 77-98.
Rao, M., Nagaraja, B.N., Kumar, S., Vasanth, M.S. and Rao, S. 2020. Incidence and clinical signs associated with septic arthritis in calves. J. Pharm. Innov. 9: 157-160.
Sastry, K.V.H., Moudgal, R.P., Mohan, J., Tyagi, J.S. and Rao, G. 2002. Spectrophotometric determination of serum nitrite and nitrate by copper–cadmium alloy. Anal. Biochem. 306: 79-82.
Srivastava, N.K., Sharma, S., Sinha, N., Mandal, S.K. and Sharma, D. 2018. Abnormal lipid metabolism in a rat model of arthritis: one possible pathway. Mol. Cell. Biochem. 448: 107-124.
Thompson, P.W. and Jones, D.D. 1987. Serum lactic dehydrogenase as a marker of joint damage in rheumatoid arthritis. Ann. Rheum. Dis. 46: 263.
Thrall, D.E. 2013. Radiographic features of bone tumors and bone infection. In: Textbook of Veterinary Diagnostic Radiology, 6th edn. Raleigh: Elsevier Health Sciences. p 307.
Tulamo, R., Bramlage, L. and Gabel, A. 1989. Sequential clinical and synovial fluid changes associated with acute infectious arthritis in the horse. Equine Vet. J. 21: 325-331.
Van Kampen, E.J. and Zijlstra, W.G. 1966. Determination of hemoglobin and its derivatives. Adv. Clin. Chem. 8: 141-187.
Wang, W., Wei, S., Luo, M., Yu, B., Cao, J., Yang, Z., Wang, Z., Goldring, M.B. and Chen, J. 2013. Oxidative stress and status of antioxidant enzymes in children with Kashin–Beck disease. Osteoarthr. Cartil. 21: 1781-1789.
Weaver, A.D. 1997. Joint conditions. In: Lameness in Cattle, P.R. Greenough and A.D. Weaver (Eds), 3rd edn. W.B. Saunders Co., Philadelphia. pp 162-170.
Wichtel, M.E., Fenwick, S.G. and Hunter, J. 2003. Septicaemia and septic arthritis in a neonatal calf caused by Lactococcus lactis. Vet. Rec. 153: 22-23.
Yýldýz, R., Beslek, M., Beydilli, Y., Özçelik, M. and Biçici, Ö. 2018. Evaluation of platelet activating factor in neonatal calves with sepsis. J. Turkish Vet. Med. Soc. 89: 66-73.
Zhang, X., Hou, L., Guo, Z., Wang, G., Xu, J., Zheng, Z., Sun, K. and Guo, F. 2023. Lipid peroxidation in osteoarthritis: Focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis. Cell Death Discov. 9: 320.
Downloads
Submitted
Published
Issue
Section
License
Copyright (c) 2026 Indian Journal of Veterinary Surgery
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.