Comparative evaluation of dexmedetomidine and tramadol as an adjunct to lignocaine for distal intravenous regional anaesthesia in buffalo calves


10 / 12

Authors

  • Sangeeta D. Khangembam Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya - 224 229 (Uttar Pradesh)
  • Anil K. Gangwar Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya - 224 229 (Uttar Pradesh)
  • Vipin K. Yadav Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya - 224 229 (Uttar Pradesh)
  • Yogendra Singh Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya - 224 229 (Uttar Pradesh)
  • K. Singh Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya - 224 229 (Uttar Pradesh)
  • Surendra P. Chakravarti Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya - 224 229 (Uttar Pradesh)
  • Rajesh K. Verma Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya - 224 229 (Uttar Pradesh)

Keywords:

Dexmedetomidine, Intravenous regional anaesthesia, Lignocaine, Tramadol

Abstract

This study evaluated a novel distal intravenous regional anaesthesia (DIVRA) technique in buffalo calves using lignocaine combined with either dexmedetomidine or tramadol. Twelve buffalo calves of either sex, affected with various surgical hoof ailments, were randomly divided into two groups. Group I received lignocaine (2 mg/kg body weight) with dexmedetomidine (2.5 µg/kg), while group II received lignocaine (2 mg/kg) with tramadol (1 mg/kg) through the common axial digital vein.

In group I, heart rate decreased for up to 50 min, whereas in group II the decrease persisted for 10 min. Pulse rate declined at 10 min in both groups. Respiratory rate decreased for 30 min in group I and for 50 min in group II. SpO₂ values showed a reduction up to 50 min in both groups. Systolic blood pressure fluctuated during the observation period, showing an initial decline in group I and increases at specific time intervals in group II. The onset of sensory and motor blockade was faster in group I, while recovery time was longer in group II.

Overall, the findings indicated that lignocaine combined with dexmedetomidine provided more effective DIVRA compared to lignocaine combined with tramadol.

Downloads

Download data is not yet available.

References

Aantaa, R. 1991. Assessment of the sedative effects of dexmedetomidine-an α2-adrenoceptor agonist, with analysis of saccadic eye movements. Pharmacol. Toxicol. 68: 394-398.

Acalovschi, I., Cristea, T., Mărgărit, S. and Gavruş, R. 2001. Tramadol added to lidocaine for intravenous regional anesthesia. Anesth. Analg. 92: 209-214.

Bansal, A., Gupta, S., Sood, D., Kathuria, S. and Tiwari, A. 2011. Bier's block using lignocaine and butorphanol. J. Anaesthesiol. Clin. Pharmacol. 27: 465-469.

Beths, T., Reid, J., Monteiro, A.M., Nolan, A.M. and Glen, J.B. 2001. Evaluation and optimisation of a target-controlled infusion system for administ ering propofol to dogs as part of a total intravenous anaesthetic technique during dental surgery. Vet. Rec. 148: 198-203.

Bhaumik, D., Singam, A. and Agrawal, N.K. 2016. The study of effect of dexmedetomidine on the characteristics of Bier's block (intravenous regional anaesthesia) when administered in addition to lidocaine for forearm and hand surgeries. J. Evid. Based Med. Healthc. 3: 4925-4931.

Chandramohan, S., Sooryadas, S., Dinesh, P.T., Jineshkumar, N.S., Remya, V., Anoop, S. and David, P.V. 2024. Multimodal balanced general anaesthesia using tiletamine-zolazepam, butorphanol, dexmedetomidine, propofol, ketamine and lignocaine in dogs. Indian J. Vet. Surg. 45: 21-26.

Cook, N.B. 2016. A lesion-oriented, life cycle approach to preventing lameness in dairy herds. In: Proceedings of 29th World Buiatrics Congress. Ireland.

Dilek, O., Yasemin, G. and Atci, M. 2011. Preliminary experience with dexmedetomidine in neonatal anesthesia. J. Anaesthesiol. Clin. Pharmacol. 27: 17 22.

Elramely, M. and Elmoutaz, H. 2016. Nalbuphine versus dexmedetomidine as an analgesic additive to lidocaine in Intravenous Regional Anesthesia (IVRA). Pain Studies and Treatment 4: 35-42.

Esmaoglu, A., Mizrak, A., Akin, A., Turk, Y. and Boyaci, A. 2005. Addition of dexmedetomidine to lidocaine for intravenous regional anaesthesia. Eur. J. Anaesthesiol. 22: 447-451.

Fazili, M.R., Shah, A.A., Beigh, A.B., Khan, A.A., Dar, A., Haq, S.A. and Dar, A.A. 2023. Revisiting pain management: auricular field block analgesia in neonatal dairy calves. Indian J. Vet. Surg. 44: 92-94.

Flacke, W.E., Flacke, J.W., Bloor, B.C., McIntee, D.F. and Sagan, M. 1993. Effects of dexmedetomidine on systemic and coronary hemodynamics in the anesthetized dog. J. Cardiothorac. Vasc. Anesth. 7: 41-49.

Gerlach, A.T. and Dasta, J.F. 2007. Dexmedetomidine: an updated review. Ann. Pharmacother. 41: 245 252.

Gupta, A., Mahobia, M., Narang, N. and Mahendra, R. 2014. A comparative study of two different doses of dexmedetomidine as adjunct to lignocaine in intravenous regional anaesthesia of upper limb surgeries. Int. J. Sci. Stud. 2: 53-62.

Haider, H.S. and Mahdi, F.A. 2013. The combination effect of lidocaine, ketamine and atracurium in IVRA. Kufa. Med. J. 9: 61-63.

Hall, J.E., Uhrich, T.D., Barney, J.A., Arain, S.R. and Ebert, T.J. 2000. Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions. Anesth. Analg. 90: 699-705.

Hassanein, A. 2016. Dexmedetomidine versus ketorolac as adjuvants for intravenous regional anesthesia. Ain. Shams. J. Anesthesiol. 9: 92.

Holmes, C. 1963. Intravenous regional analgesia-a useful method of producing analgesia of the limbs. Lancet 281: 245-247.

Kalema-Zikusoka, G., Horne, W.A., Levine, J. and Loomis, M. 2003. Comparison of the cardiorespiratory effects of medetomidine butorphanol-ketamine and medetomidine butorphanol-midazolam in patas monkeys (Erythrocebus patas). J. Zoo Wildl. Med. 34: 47-52.

Kognole, S.M., Barvalia, D.R., Patil, D.B., Kelawala, N.H., Parikh, P.V. and Tank, P.H. 2004. Intravenous regional anaesthesia of forelimb using bupivacaine, pentazocine, ketamine and buprenorphine alone or in combinations in calves. Indian J. Vet. Surg. 25: 15-17.

Kuusela, E., Raekallio, M., An ila, M., Falck, I., Molsa, S.H. and Vainio, O. 2000. Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs. J. Vet. Pharmacol. Ther. 23: 15 20.

Kuusela, E., Raekallio, M., Väisänen, M., Mykkanen, K., Ropponen, H. and Vainio, O. 2001. Comparison of medetomidine and dexmedetomidine as premedicants in dogs undergoing propofol isoflurane anesthesia. Am. J. Vet. Res. 62: 1073-1080.

Martin, E., Ramsay, G., Man, J. and Sum-Ping, S.J. 2003. The role of the α2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit. J. Intensive Care Med. 18: 29-41.

Mohr, B. 2006. Safety and effectiveness of intravenous regional anesthesia (Bier block) for outpatient management of forearm trauma. Can. J. Emerg. Med. 8: 247-250.

Muir, W.W. and Gadawski, J.E. 1998. Respiratory depression and apnea induced by propofol in dogs. Am. J. Vet. Res. 59: 157-161.

Muir, W.W., Hubbell, J.A.E., Bednarski, R.M. and Lerche, P.E. 2007. Handbook of Veterinary Anesthesia, 5th edn. College of Veterinary Medicine, Ohio USA. pp 96-97.

Nasr, Y.M. and Waly, S.H. 2012. Lidocaine-tramadol versus lidocaine-dexmedetomidine for intravenous regional anesthesia. Egypt J. Anaesth. 28: 37-42.

Sheth, P.P., Shah, V. and Soni, B. 2016. Randomized controlled study of intravenous regional anaesthesia for forearm and hand surgery: comparison of lignocaine, lignocaine with ketamine and lignocaine with dexmedetomidine. Int. J. Sci. Res. 5: 154-157.

Tien, L.Y.H., Morgan, W.H., Cringle, S.J. and Yu, D.Y. 2023. Optimal calculation of mean pressure from pulse pressure. Am. J. Hypertens. 36: 297-305.

Venn, R., Newman, P. and Grounds, R. 2003. A phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit. Intensive Care Med. 29: 201-207.

Yadav, V.K., Gangwar, A.K., Khangembam, S.D., Goyal, R.P. and Kumar, R. 2021. Development of novel intravenous regional anaesthetic technique for desensitization of hoof in ca le. Indian J. Anim. Sci. 91: 280-284.

Yadav, V.K., Gangwar, A.K., Khangembam, S.D., Yadav, Y. and Goyal, R.P. 2023. Comparison of lidocaine and its combination with ketamine for distal intravenous regional anesthesia (DIVRA) in bovines. Vet. Arh. 93: 407-416.

Yavari, S., Khraim, N., Szura, G., Starke, A., Engelke, E., Pfarrer, C., Hopster, K., Schmicke, M., Kehler, W., Heppelmann, M. and Kästner, S.B.R. 2017. Evaluation of intravenous regional anaesthesia and four-point nerve block efficacy in the distal hind limb of dairy cows. BMC Vet. Res. 13: 1-11.

Submitted

2026-06-12

Published

2026-06-15

Issue

Section

Research Articles

How to Cite

Khangembam, S. D., Gangwar, A. K., Yadav, V. K., Singh, Y., Singh, K., Chakravarti, S. P., & Verma, R. K. (2026). Comparative evaluation of dexmedetomidine and tramadol as an adjunct to lignocaine for distal intravenous regional anaesthesia in buffalo calves. Indian Journal of Veterinary Surgery, 47(01), 31-36. https://epubs.icar.org.in/index.php/IJVS/article/view/180070