Cyclophosphamide Induced Testicular Toxicity Mechanisms aAnd Ameliorative Agents
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Authors
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Matam SriDeepthi
1College of Veterinary Science, Rajendranagar, PVNR Telangana Veterinary University, Rajendranagar, Hyderabad
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Kondampati Kasturi Devi
College of Veterinary Science, Warangal PVNR Telangana Veterinary University, Rajendranagar, Hyderabad
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Matukuamli Usha rani
College of Veterinary Science, Warangal PVNR Telangana Veterinary University, Rajendranagar, Hyderabad
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Boinepally Ramya
College of Veterinary Science, Warangal PVNR Telangana Veterinary University, Rajendranagar, Hyderabad
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Beesam Srinu
College of Veterinary Science, Warangal PVNR Telangana Veterinary University, Rajendranagar, Hyderabad
Keywords:
Cyclophosphamide, Testicular toxicity, Oxidative stress, AntioxidantsAbstract
Cyclophosphamide is an alkylating agent that is widely known for its anticancer and immunosuppressive properties used in various cancerous and autoimmune diseases. Acrolein and phosphoramide mustard, are its toxic metabolites, majorly involved in toxic effects such as induction of oxidative stress that can induce oxidative damage in tissues. The free radicles thus produced are implicated in gonad toxicity, hepatic and kidney disorders, hemorrhagic cystitisetc. Clinical efficacy of cyclophosphamide is restricted because of its toxicity. The reproductive system due to presence of rapidly dividing cells is highly vulnerable to cyclophosphamide toxicity. Especially male subjects treated with cyclophosphamide demonstrated severe alterations in testis and epididymis as well as disturbed gonadotropin and reproductive hormone levels. Several studies suggested the usage of medicinal plants with antioxidant properties along with cyclophosphamide could protect against its organ toxicity. Supplementation of the dietary antioxidant’s during chemotherapy can reduce the drug induced toxic side effects and can further improvise the response to therapy.
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