Pituitary Gland Cyst in a Bull Mastiff Dog

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  • N. Babu Prasath Department of Veterinary Pathology, Veterinary College and Research Institute, Orathanadu, TANUVAS, Thanjavur – 614 625
  • J. Selvaraj Department of Veterinary Pathology, Veterinary College and Research Institute, Orathanadu, TANUVAS, Thanjavur – 614 625



Acid mucin, dog, histochemistry, pituitary gland cyst, Rathke’s cyst


The paper describes the incidence and histochemistry of pituitary cyst in a dog. A nine months old Bull Mastiff male dog was presented for necropsy. On examination of cranial cavity and brain, a thin membranous fluid filled cyst of 2 mm was found attached with the pituitary gland suprasellar region. Cyst was thin walled with fibrous tissue encircling colloid content of homogenous nature. On histochemistry by Alcian blue-PAS staining, the colloid showed positive for acid mucin. Acid mucin (polysalic acid) derived from embryogenesis constitutes colloidal protein of the pituitary cyst.


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Duperrier C, Fusellier M, Lenaerts H, Drut A and Hernandez J (2020). A case of central diabetes insipidus associated with a congenital cyst of the sella turcica in a young cat. J. Feline Med Surg Open Rep. 6(2):2055116920935017.

Karavitaki N and Wass JA (2009). Non-adenomatous pituitary tumours. Best Pract Res Clin Endocrinol Metab. 23: 651-665.

Layton C and Bancroft JD (2019). Theory and Practice of Histological Techniques. In: Suvarna SK, Layton C, Bancroft JD, eds. UK: Elsevier, 126-138.

Mukherjee JJ, Islam N, Kaltsas G, Lowe DG, Charlesworth M, Afshar F, Trainer PJ, Monson JP, Besser GM and Grossman AB (1997). Clinical, radiological and pathological features of patients with Rathke’s cleft cysts: tumors that may recur. J. Clin Endocrinol Metab. 82 (7): 2357-2362.

Osborn AG and Preece MT (2006). Intracranial cysts: radiologic-pathologic correlation and imaging approach. Radiol. 239: 650-664.

Polledo L, Grinwis GC, Graham P, Dunning M and Baiker K (2018). Pathological findings in the pituitary glands of dogs and cats. Veterinary pathology. 55(6):880-8.

Ringel SP and Bailey OT (1972). Rathke's cleft cyst. J. Neurol Neurosurg. Psychiatry 35: 693-697.

Rosol TJ and Grone A (2016). Endocrine glands. In: MG Maxie ed. Jubb, Kennedy & Palmer’s Pathology of Domestic Animals. 6th edn, Vol 3. Philadelphia, PA: Elsevier, 279.

Schiefer B and Hanichen T (1967). On the knowledge and possible significance of hypophyseal cysts in dogs. Acta Neuropathol. 7(3): 232-241.

Schnaar RL, Gerardy-Schahn R and Hildebrandt H (2014). Sialic Acids in the Brain: Gangliosides and Polysialic Acid in Nervous System Development, Stability, Disease, and Regeneration. Physiol Rev. 94(2): 461-518.

Teramoto A, Hirakawa K, Sanno N and Osamura Y (1994). Incidental pituitary lesions in 1,000 unselected autopsy specimens. Radiol. 193: 161–164.

Trifanescu R, Ansorge O, Wass JA, Grossman AB and Karavitaki N (2012). Rathke’s cleft cysts. Clin Endocrinol. 76(2): 151-160.

Villanueva-Cabello TM, Gutiérrez-Valenzuela LD, Salinas-Marín R, López-Guerrero DV and Martínez-Duncker I (2022). Polysialic acid in the immune system. Front Immunol. 12: 823637.





How to Cite

N. Babu Prasath, & J. Selvaraj. (2024). Pituitary Gland Cyst in a Bull Mastiff Dog . The Indian Veterinary Journal, 101(2), 75-76. https://doi.org/10.62757/IVA.2024.101.2.75-76