Correlation Analysis of Antimicrobial Resistance Coexistence among Bacterial Pathogens Associated with Bovine Mastitis
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Authors
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Elamurugan Appavoo
Department of Veterinary Microbiology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamilnadu, India- 600007
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Ranjithkumar M
Department of Clinics, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamilnadu, India- 600 007
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Jayanthy C
Department of Clinical Medicine, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamilnadu, India- 600 007
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Saravanan S
Indian Council of Agricultural Research -Krishi Vigyan Kendra, Madurai, Tamilnadu, India – 625 104
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Samuel Masilamoni Ronald B
Department of Veterinary Microbiology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamilnadu, India- 600007
Keywords:
Antimicrobial resistance, Predictive Multiple Antimicrobial Resistance Index, Correlation of AMRAbstract
In the era of AMR,it is essential to understand and correlate AMR among pathogens of clinical importance. Analysis of AMR pattern among bovine mastitis pathogens revealed that isolates ofStaphylococcus spp.,Streptococcus spp.and Klebsiella spp. were either multior extensivelydrug-resistant, and none of the E. coli were resistant to multiple antimicrobials. Further, pMAR index revealed a7.89 – 15.13 % possibility that an isolate mightnot be amenable to first-line antimicrobials. Correlation of coexisting resistanceindicated a weak correlation among β-lactams and a moderate to weak correlation between β-lactams and gentamicin. This analysis will shed more light onto AMR coexistence and might help clinicians in choosing correct antimicrobials.
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References
Awandkar SP, Kulkarni MB and Khode NV (2022). Bacteria from bovine clinical mastitis showed multiple drug resistance. Vet ResCommuni, 46(1): 147–158.
ChengJ, Qu W, Barkema HW, Nobrega DB, Gao J, Liu G, De Buck J, Kastelic JP, Sun H and Han B (2019). Antimicrobial resistance profiles of 5 common bovine mastitis pathogens in large Chinese dairy herds. J Dairy Sci, 102(3): 2416–2426.
Elamurugan A, Ranjithkumar M, Jayanthy C, Sumathra M, and Samuel Masilamoni Ronald B (2024). Phenotypes of antimicrobial resistance in bovine mastitis pathogens and analysis of risk factors associated with mastitis. Indian Vet J. (Article in Press).
Fuhrmeister, AS and Jones, RN (2019). The Importance of Antimicrobial Resistance Monitoring Worldwide and the Origins of SENTRY Antimicrobial Surveillance Program. Open forum Infect Dis, 6 (Suppl 1): S1–S4.
Gajdács M, Bátori Z and Burián K (2021). Interplay between Phenotypic Resistance to Relevant Antibiotics in Gram-Negative Urinary Pathogens: A Data-Driven Analysis of 10 Years' Worth of Antibiogram Data. Life (Basel, Switzerland), 11(10):1059.
Gajdács M, Bátori Z, Ábrók M, Lázár A and Burián K (2020). Characterization of Resistance in Gram-Negative Urinary Isolates Using Existing and Novel Indicators of Clinical Relevance: A 10-Year Data Analysis. Life (Basel, Switzerland), 10(2): 16.
Haq IU, Kamal M, SwelumAA, Khan S, Ríos-Escalante PRL and Usman T (2024). Alarming multidrug resistance in Staphylococcus aureus isolated from raw milk of cows with subclinical mastitis: Antibiotic resistance patterns and occurrence of selected resistance genes. PloS one, 19(5): e0301200.
Kovačević Z, Samardžija M, Horvat O, Tomanić D, Radinović M, Bijelić K, Vukomanović,AG and Kladar N (2022). Is There a Relationship between Antimicrobial Use and Antibiotic Resistance of the Most Common Mastitis Pathogens in Dairy Cows?.Antibiotics (Basel, Switzerland), 12(1): 3.
Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y,Falagas ME, Giske CG and Paterson DL (2012). Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: An international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect,18: 268–281.
Mukaka MM (2012). A guide to appropriate use of Correlation coefficient in medical research. Malawi Med. J, 24: 69–71.
Mutua F, Sharma G, Grace D, Bandyopadhyay S, Shome B and Lindahl J (2020). A review of animal health and drug use practices in India, and their possible link to antimicrobial resistance. Antimicrob Resist Infect Control,9(1):103.
Naranjo-Lucena, A and Slowey R (2023). Invited review: Antimicrobial resistance in bovine mastitis pathogens: A review of genetic determinants and prevalence of resistance in European countries. J Dairy Sci, 106(1): 1–23.
Osman K, Alvarez-OrdóñezA, Ruiz L, Badr J, ElHofy F, Al-Maary KS, Moussa IMI, Hessain AM, Orabi A, Saad, A and Elhadidy M (2017).Antimicrobial resistance and virulence characterization of Staphylococcus aureus and coagulase-negative staphylococci from imported beef meat. Ann. Clin. Microbiol. Antimicrob.16:35.
Van Boeckel T, Brower C, Gilbert M, Grenfell B, Levin S, Robinson TP, Teillant A and Laxminarayan R (2015) Global trends in antimicrobial use in food animals. PNAS, 112(18):5649–5654.
Velazquez-Meza ME, Galarde-López M, Carrillo-Quiróz, B and Alpuche-Aranda CM (2022). Antimicrobial resistance: One Health approach. Vet World, 15(3): 743–749.
Vijay D, Bedi JS, Dhaka P, Singh R, Singh J, Arora AK and Gill JPS (2023). Monitoring of antimicrobial usage among adult bovines in dairy herds of Punjab, India: A quantitative analysis of pattern and frequency. Front Vet Sci,10:1089307.
