Acute Encephalitis Syndrome and its alleged litchi (Litchi chinensis) connection—A review and status
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https://doi.org/10.56093/ijas.v86i3.56827
Keywords:
Acute Encephalitis Syndrome (AES), Blood sugar, Litchi, α-methylenecyclopropylglycine (MCPG), VirusAbstract
In recent times, Acute Encephalitis Syndrome (AES), an unexplained mysterious disease is affecting people, especially young children below the age of 15 years in few Asian countries. Several hypothesis and causal factors are being suspected and studied by the researchers.Despite the stringent efforts, the causal agent of AES has not been identified till date and researchers all over the world are striving to find out the cause and remedy of this fatal disease. The concurrence of the AES, in temporal dimensions in most of the places and spatial dimension in few cases with the seasonal maturity of litchi (Litchi chinensis Sonn.) fruits has occasioned in the fruit being associated and judged as a possible causal agent of AES. However, the delicious litchi fruit has been consumed since centuries and thus the alleged association wants critical examination and investigation. The symptoms of the AES disease point towards a viral etiology, and several of the enteroviruses are known to cause encephalitis. This review article is an attempt to present the various supposed causal factors of AES, the critical gaps that question the association between the litchi fruits and AES and some of the serious misgivings to refute the suspected association between the consumption of litchi fruits and AES.Downloads
References
AES nature varies in Gaya, Muzaffarpur. The Times of India Feb 16, 2015. DOI: http://timesofindia.indiatimes.com/city/patna/AES-naturevariesinGayaMuzaffarpur/articleshow/46256748.cms
Lakshanon ke sath AES ne jagahbhibadli.PrabhatKhabar. June 13, 2015. DOI: http://epaper.prabhatkhabar.com/519942/MUZAFFARPUR-City/CITY#page/9/2
Bandyopadhyay B, Chakraborty D, Ghosh S, Mishra R and Rahman M. 2015. Epidemiological investigation of an outbreak of acute encephalitis syndrome (AES) in Malda district of West Bengal, India. Clinical Microbiology 4: 181. DOI:10.4172/ 2327-5073.1000181. DOI: https://doi.org/10.4172/2327-5073.1000181
Besra S E, Sharma R M and Gomes A. 1996. Antiinflammatory effect of petroleum ether extract of leaves of Litchi chinensis Gaertn (Sapindaceae). Journal of Ethnopharmacology 54(1): 1–6. DOI: https://doi.org/10.1016/0378-8741(96)01440-7
Bhoopat L, Srichairatanakool S, Kanjanapothi D, Taesotikul T, Thananchai H, Bhoopat T. 2011.Hepatoprotective effects of lychee (Litchi chinensis Sonn.): A combination of antioxidant and anti-apoptotic activities. Journal of Ethnopharmacology 136(1): 55–66. DOI: https://doi.org/10.1016/j.jep.2011.03.061
Cheval J, Sauvage V, Frangeul L, Dacheux L, Guigon G. 2011. Evaluation of high-throughput sequencing for identifying known and unknown viruses in biological samples. Journal of Clinical Microbiology 49: 3 268–75. DOI: https://doi.org/10.1128/JCM.00850-11
Chi J W, Tang X J, Zhang M W, Xu Z H, Zhang Y, Wei Z C, Li J X, Zhang R F. 2005. Study on the processing technology of litchi health oral solution. Food Science and Technology 26(7): 63–5.
Devalaraja S, Jain S and Yadav H. 2011. Exotic fruits as therapeutic complements for diabetes, obesity and metabolic syndrome.Food Research International 44(7): 1 856–65. DOI: https://doi.org/10.1016/j.foodres.2011.04.008
Dinesh D S, Pandey K, Das V N R, Topno R K, Kesari S, Kumar V, Ranjan A, Sinha P K and Das P. 2013. Possible factors causing acute encephalitis syndrome outbreak in Bihar, India. International Journal of Current Microbiology and Applied Sciences 2(12): 531–8.
Geevarghese G, Arankalle V A, Jadi R, Kanojia P C, Joshi M Vand Mishra A C. 2005. Detection of Chandipura virus from sand flies in the genus Sergentomyia (Diptera: Phlebotomidae) at Karimnagar district, Andhra Pradesh, India. Journal of Medical Entomology 42: 495–6. DOI: https://doi.org/10.1093/jmedent/42.3.495
Ghisla S, Melde K, Zeller B D and Boschert W. 1990. Mechanisms of enzyme inhibition by hypoglycin, methylenecyclopropylglycine and their metabolites.Progress in Clinical and Biological Research. 321: 185–92.
Gray D O and Fowden L. 1962. (Methylenecyclopropyl) glycine from litchi seeds. Biochemistry Journal 82: 385. DOI: https://doi.org/10.1042/bj0820385
Ibrahim S R M and Mohamed G A. 2015. Litchi chinensis: medicinal uses, phytochemistry, and pharmacology. DOI: http://dx.doi.org/10.1016/j.jep.2015.08.054. DOI: https://doi.org/10.1016/j.jep.2015.08.054
Jiang G, Lin S, Wen L, Jiang Y, Zhao M, Chen F, Prasad K N, Duan X and Yang B. 2013. Identification of a novel phenolic compound in litchi (Litchi chinensis Sonn.) pericarp and bioactivity evaluation. Food Chemistry 136: 563–8. DOI: https://doi.org/10.1016/j.foodchem.2012.08.089
John T J and Das M. 2014. Acute encephalitis syndrome in children in Muzaffarpur: hypothesis of toxic origin. Current Science 106(1184-9,10): 1 184–85.
Joshi R, Kalantri S P, Reingold A and Colford J M Jr. 2012. Changing landscape of acute encephalitis syndrome in India: a systematic review. National Medical Journal of India 25: 212– 20.
Kitadate K, Aoyagi K and Homma K. 2014. Effect of lychee fruit extract (oligonol) on peripheral circulation, a pilot study. Natural Medicine Journal 6(7): 31–5.
Kong F, Zhang M, Liao S, Yu S, Chi J and Wei Z. 2010. Antioxidant activity of polysaccharide-enriched fractions extracted from pulp tissue of Litchi chinensis Sonn. Molecules 15: 2 152–65. DOI: https://doi.org/10.3390/molecules15042152
Laserson K. 2013. India’s EIS officers investigate mysterious illness affecting children in Muzaffarpur. Updates from the Field 12: 1–2.
Lee S J, Park W H, Park S D and Moon H I. 2009. Aldose reductase inhibitors from Litchi chinensis Sonn. Journal of Enzyme Inhibition and Medicinal Chemistry 24: 957–9. DOI: https://doi.org/10.1080/14756360802560867
Li D, Agnihotri G, Dakoji S, Oh E, Lantz M and Liu H W. 1999. The toxicity of methylenecyclopropylglycine: studies of the inhibitory effects of (Methylenecyclopropyl) formyl-CoA on enzymes involved in fatty acid metabolism and the molecular basis of its inactivation of Enoyl-CoA hydratases. Journal of the American Chemical Society 121(39): 9 034–42. DOI: https://doi.org/10.1021/ja991908w
Liu L, Xie B, Cao S, Yang E, Xu X and Guo S. 2007. A-type procyanidins from Litchi chinensis pericarp with antioxidant activity. Food Chemistry 105: 1 446–51. DOI: https://doi.org/10.1016/j.foodchem.2007.05.022
Liu S C, Lin J T, Wang C K, Chen H Y and Yang D J. 2009. Antioxidant properties of various solvent extracts from lychee (Litchi chinenesis Sonn.) flowers. Food Chemistry 114: 577– 81. DOI: https://doi.org/10.1016/j.foodchem.2008.09.088
Lv Q, Si M, Yan Y, Luo F, Hu G, Wu H, Sun C, Li X and Chen K. 2014. Effects of phenolic-rich litchi (Litchi chinensis Sonn.) pulp extracts on glucose consumption in human HepG2 cells. Journal of Functional Foods 7: 621–9. DOI: https://doi.org/10.1016/j.jff.2013.12.023
Mahattanatawee K, Manthey J A, Luzio G, Talcott S T, Goodner K, Baldwin E A. 2006. Total antioxidant activity and fiber content of select Florida-grown tropical fruits. Journal of Agricultural and Food Chemistry 54: 7 355–63. DOI: https://doi.org/10.1021/jf060566s
Melde K, Buettner H, Boschert W, Wolft H P O and Ghisla S. 1989. Mechanism of hypoglycaemic action of methylenecyclopropylglycine. Biochemical Journal 259(3): 921–4. DOI: https://doi.org/10.1042/bj2590921
Melde K, Jackson S, Bartlett K, Sherratt H S A and Ghisla S. 1991.Metabolic consequences of methylenecyclopropylglycine poisoning in rats. Biochemistry Journal 274: 395–400. DOI: https://doi.org/10.1042/bj2740395
Obrosova I G, Chung S S and Kador P F. 2010. Diabetic cataracts: mechanisms and management. Diabetes Metabolism Research and Reviews 26: 172–80. DOI: https://doi.org/10.1002/dmrr.1075
Ogasawara J, Kitadate K, Nishioka H, Fujii H, Sakurai T, Kizaki T, Izawa T, Ishida H and Ohno H. 2011. Comparison of the effect of oligonol, a new lychee fruit derived low molecular form of polyphenol, and epigallocatechin 3-gallate on lipolysis in rat primary adipocytes. Phytotherapy Research 25: 467– 71. DOI: https://doi.org/10.1002/ptr.3296
Paireau J, Tuan N H, Lefrancois R, Buckwalter M R and Nghia N D. 2012. Litchi-associated acute encephalitis in children, Northern Vietnam, 2004-2009.Emerging Infectious Diseases 18: 1 817–24. DOI: https://doi.org/10.3201/eid1811.111761
Prasad K N, Yang B, Yang S, Chen Y, Zhao M, Ashraf M and Jiang Y. 2009. Identification of phenolic compounds and appraisal of antioxidant and antityrosinase activities from litchi (Litchi sinensis Sonn.) seeds. Food Chemistry 116: 1–7. DOI: https://doi.org/10.1016/j.foodchem.2009.01.079
Prior R L and Gu L. 2005. Occurrence and biological significance of proanthocyanidins in the American diet. Phytochemistry 66: 2 264–80. DOI: https://doi.org/10.1016/j.phytochem.2005.03.025
Sakurai T, Nishioka H, Fujii H, Nakano N, Kizaki T, Radak Z, Izawa T, Haga S and Ohno H. 2008. Antioxidative effects of a new lychee fruit-derived polyphenol mixture, oligonol, converted into a low-molecular form in adipocytes. Biosciences, Biotechnology and Biochemistry 72: 463–76. DOI: https://doi.org/10.1271/bbb.70567
Sapkal G N, Bondre V P, Fulmali P V, Patil P, Gopalkrishna V, Dadhania V, Ayachit V M, Gangale D, Kushwaha K P, Rathi A K, Chitambar S D, Mishra A C, Gore M M. 2009. Enteroviruses in patients with acute encephalitis, Uttar Pradesh, India. Emerging Infectious Diseases 15: 295–8. DOI: https://doi.org/10.3201/eid1502.080865
Shrivastava A, Srikantiah P, Kumar A, Bhushan G, Goel K, Kumar S, Kumar T, Kumar R M, Pandey R, Pathan P, Tulsian Y, Pappanna M, Pasi A, Pradhan A, Singh P, Somashekar D, Velayudhan A, Yadav R, Chhabra M, Mittal V, Khare S, Sejvar J J, Dwivedi M, Laserson K, Earhart K C, Sivaperumal P, Kumar A R, Chakrabarti A, Thomas J, Schier J, Singh R, Singh R S, Dhariwal A C and Chauhan L S. 2015. Outbreaks of unexplained neurologic illness — Muzaffarpur, India, 2013– 2014. Morbidity and Mortality Weekly Report 64(3): 49–53.
Singh G, Nath V, Pandey S D, Ray P K and Singh H S. 2012. The Litchi. Food and Agriculture Organization of The United Nations, New Delhi.
Souza M, Singh R, Reddy P, Hukkeri V, Byahatti V. 2006. Hepatoprotective activity of fruit pulp extract of Litchi chinensis Sonner on carbon tetrachloride induced hepatotoxicity in albino rats. The Internet Journal of Alternative Medicine 4(1). DOI: https://doi.org/10.5580/570
Su D, Ti H, Zhang R, Zhang M, Wei Z, Deng Y, Guo J. 2014. Structural elucidation and cellular antioxidant activity evaluation of major antioxidant phenolics in lychee pulp. Food Chemistry 158: 385–91. DOI: https://doi.org/10.1016/j.foodchem.2014.02.134
Vashishtha V M, Kumar A, John T J and Nayak N C. 2007. Cassia occidentalis poisoning causes fatal coma in children in western Uttar Pradesh. Indian Pediatrics 44: 522–5.
Wacharapluesadee S, Lumlertdacha B, Boongird K, Wanghongsa S, Chanhome L, Rollin P, Stockton P, Rupprecht C E, Ksiazek T G and Hemachudha T. 2005. Bat Nipah virus, Thailand. Emerging Infectious Diseases 11: 1 949–51. DOI: https://doi.org/10.3201/eid1112.050613
Wall M M. 2006.Ascorbic acid and mineral composition of longan (Dimocarpus longan), lychee (Litchi chinensis) and rambutan (Nephelium lappaceum) cultivars grown in Hawaii. Journal of Food Composition and Analysis 19: 655–63. DOI: https://doi.org/10.1016/j.jfca.2005.12.001
Walsh J F, Molyneux D H and Birley M H. 1993. Deforestation: effects on vector-borne disease. Parasitology 106: S55–75. DOI: https://doi.org/10.1017/S0031182000086121
Wang L J, Lou G D, Ma Z J and Liu X M. 2011. Chemical constituents with antioxidant activities from litchi (Litchi chinensis Sonn.) seeds. Food Chemistry 126(3): 1 081–87. DOI: https://doi.org/10.1016/j.foodchem.2010.11.133
Wang X, Wei Y, Yuan S, Liu G, Zhang Y L J, Wang W. 2006a. Potential anticancer activity of litchi fruit pericarp extract against hepatocellular carcinoma in vitro and in vivo. Cancer Letters 239: 144–50. DOI: https://doi.org/10.1016/j.canlet.2005.08.011
Wang X, Yuan S, Wang J, Lin P, Liu G, Lu Y, Zhang J, Wang W and Wei Y. 2006b. Anticancer activity of litchi fruit pericarp extract against human breast cancer in vitro and in vivo. Toxicology and Applied Pharmacology 215: 168–78. DOI: https://doi.org/10.1016/j.taap.2006.02.004
Wang Y, Wang H C, Hu Z Q, Chen H B, Hu G B, Huang X M, Zhou Z K. 2010. Litchi good for health from skin to heart: An overview of litchi functional activities and compounds. Proceedings of 3rd IS on Longan, Lychee and other Fruit Trees in Sapindaceae family. Qiu Dongliang et al. (Eds). Acta Horticulturae 863: 645–52. DOI: https://doi.org/10.17660/ActaHortic.2010.863.91
Wen L, Wu D, Jiang Y, Prasad K N, Lin S, Jiang G, He J, Zhao M, Luo W and Yang B. 2014. Identification of flavonoids in litchi (Litchi chinensis Sonn.) leaf and evaluation of anticancer activities. Journal of Functional Foods 6: 555–63. DOI: https://doi.org/10.1016/j.jff.2013.11.022
Zhang R, Zeng Q, Deng Y, Zhang M, Wei Z, Zhang Y and Tang X. 2013. Phenolic profiles and antioxidant activity of litchi pulp of different cultivars cultivated in Southern China. Food Chemistry 136: 1 169–76. DOI: https://doi.org/10.1016/j.foodchem.2012.09.085
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