Low haemoglobin density as an anaemic indicator in canine babesiosis
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Keywords:
Anaemia, Canine babesiosis, Iron deficiency, LHDAbstract
Low Hemoglobin Density (LHD) is related to functional iron availability and hemoglobin content. To assess the use of LHD as an anaemic indicator in canine babesiosis, 108 dogs with symptoms of canine babesiosis were selected and screened for disease by polymerase chain reaction. Blood samples were collected for estimating haematological variables, serum iron, TIBC, UIBC and LHD. Based on the haemoglobin, PCV and erythrocyte count the animals were grouped into anaemic and non-anaemic populations. LHD% was higher in the anaemic population (P<0.001) and it was negatively correlated to haemoglobin, packed cell volume, erythrocytes, MCHC and serum iron. LHD% was highly depend on serum iron (P<0.001). Receiver operating characteristics (ROC) curve analysis revealed LHD was 100.00% specific and 80.43% sensitive in identifying the functional iron deficient anaemia with cut-off value of 1.83%. This study reveals that LHD is a cost-effective parameter for identifying the functional iron deficient anaemia in canine babeisosis.
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References
Aird, B. (2000). Schalm’s veterinary hematology. 5th ed., Philadelphia. Lippincott Williams & Wilkins, pp. 140-142.
Bovy, C., Gothot, A., Delanaye, P., Warling, X., Krzesinski, J.M and Beguin, Y. (2007). Mature erythrocyte parameters as new markers of functional iron deficiency in haemodialysis: sensitivity and specificity. Nephrology Dialysis Transplantation, 22(4):1156–1162
Brugnara, C. (2003). Iron deficiency and erythropoiesis: new diagnostic approaches. Clinical Chemistry, 49(10)1573–1578.
Coles, E.H. (1986). Veterinary clinical pathology. 4th ed., Philadelphia. W.B. Saunders.
Coyne, D. (2006). Iron indices: what do they really mean? Kidney International, 101: S4–S8.
Lieu, P.T., Heiskala, M., Peterson, P. A. and Yang, Y. (2001). The roles of iron in health and disease. Molecular Aspects of Medicine, 22(1–2):1–87.
Lobetti, R.G. (2003). Hematological changes in TBDs. Proceedings of the 21st American College of Veterinary Internal Medicine forum, Charlotte, NC, pp. 554–556.
Mast, A.E., Blinder, M.A., Lu, Q., Flax, S and Dietzen, D.J. (2002), Clinical utility of the reticulocyte hemoglobin content in the diagnosis of iron deficiency. Blood, 99(4):1489–1491.
McCown, J.L and Specht, A.J. (2011). Iron homeostasis and disorders in dogs and cats: A review. Journal of the American Animal Hospital Association,47:151-160.
Mitchell, K and Kruth, S. (2010). Immune mediated hemolyticanemia and other regenerative anemias. In: textbook of veterinary internal medicine diseases of dog and cat (7thed.). W.B Saunders Publications, Philadelphia. pp. 772.
Morrison, W.B. (2005). Textbook of Veterinary Internal Medicine diseasesof dogs and cats.6th ed. Philadelphia. Elsevier Saunders, pp. 211-215.
Schaefer, D.M.W and Stokol, T. (2015). The utility of reticulocyte indices in distinguishing iron deficiency anemia from anemia of inflammatory disease, portosystemic shunting, and breed-associated microcytosis in dogs. Veterinary Clinical Pathology, 44:109–119.
Solano-Gallego, L and Baneth, G. (2011). Babesiosis in dogs and cats expanding parasitological and clinical spectra. Veterinary Parasitology, 181:48–60.
Urrechaga, E. (2016) Low Hbdensity (LHD %) in the detection of atentiron deficiency in non-anemic premenopausal women. Journal of Human Nutrition & Food Science, 4(4):1094.
Urrechaga, E., Borque, L and Escanero, J.F. (2010). Erythrocyte and reticulocyte indices on the LH 750 as potential markers of functional iron deficiency. Anemia, Article ID: 625919.
Urrechaga, E., Borque, L and Escanero, J.F. (2012). Low Hemoglobin Density (LHD %) potential marker of iron availability. International Journal of Laboratory Hematology, 34:47-51.
Urrechaga, E. (2010). The new mature red cell parameter, low haemoglobin density of the Beckman-Coulter LH750: clinical utility in the diagnosis of iron deficiency. International Journal of Laboratory Hematology, 32:144-150.
Vieth, J.T and Lane, D.R. (2017).Anemia. Hematology/Oncology Clinics of North America, 31:1045–1060.
Wians, F.H., Urban, J.E., Keffer, J.H and Kroft, S.H. (2001). Discriminating between iron deficiency anemia and anemia of chronic disease using traditional indices of iron status vstransferrin receptor concentration. American Journal of Clinical Pathology, 115(1):112-118.
Zamokas, G., Grigonis, A., Karveliene, B., Daunoras, G., Babickaite, L and Sapaliene, I. (2014).Importance of haematological changes in diagnosing canine babesiosis. VeterinarijaIr Zootechnika, 67(89):94-98.
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