Evaluation of stability of reconstituted live attenuated Peste des Petits Ruminants (PPR), Sheep Pox and Goat Pox vaccines

M. Bora; S. Arya,; Sahzad; T. V. S. Rao

doi:10.56093/ijvasr.v47i6.138227

Authors

M. Bora Brilliant Bio Pharma Private Limited, I.D.A, Pashamylaram, Hyderabad, Telangana
S. Arya, Brilliant Bio Pharma Private Limited, I.D.A, Pashamylaram, Hyderabad, Telangana
Sahzad Brilliant Bio Pharma Private Limited, I.D.A, Pashamylaram, Hyderabad, Telangana
T. V. S. Rao Brilliant Bio Pharma Private Limited, I.D.A, Pashamylaram, Hyderabad, Telangana

https://doi.org/10.56093/ijvasr.v47i6.138227

Keywords:

Peste des petits ruminants virus, Sheep pox virus, Goat pox virus, Vaccines, Stabilizers, Reconstitution, Thermostability

Abstract

In the present study, the thermostability of live attenuated Peste des Petits ruminants (PPR), sheep pox and goat pox vaccines were assessed for their stability at 5±3°C, 25±1°C and 36±1°C in reconstituted form. All the vaccine batches maintained the minimum infectious titre in their reconstituted form (2.5 log 10 CCID 50 /dose for PPR and 3 log10 CCID 50/dose for sheep/goat pox) when stored at 36±1°C for at least 20 hrs. These live attenuated vaccines can be used within 8 hrs of reconstitution for immunization of animals in tropical field situations or during cold chain failures by delivering the required quantity of vaccine dose as they are found to be stable in their reconstituted form at ambient as well as at higher temperatures.

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