DEMONSTRATION OF ANTIVIRAL ACTIVITY OF IVERMECTIN AGAINST R2B STRAIN OF NEWCASTLE DISEASE VIRUSINFECTED 9- DAY OLD CHICKEN EGGS  2

T. Jagadeesh; G. Sathish; M. Parthiban; P. Raja; G. Sarathchandra

doi:10.56093/ijvasr.v52i4.145249

Authors

T. Jagadeesh Ph. D. Scholar, Department of Veterinary Pharmacology and Toxicology, Madras Veterinary College, TANUVAS, Chennai - 600 007
G. Sathish Ph. D. Scholar, Department of Animal Biotechnology, Madras Veterinary College, TANUVAS, Chennai-7
M. Parthiban Professor, Department of Animal Biotechnology, Madras Veterinary College, TANUVAS, Chennai - 7
P. Raja Assistant Professor, Department of Animal Biotechnology, Madras Veterinary College, Chennai –7
G. Sarathchandra Professor and Head, Pharmacovigilance Laboratory for Animal Feed and Food Safety, TANUVAS, MMC, Chennai - 600 051

https://doi.org/10.56093/ijvasr.v52i4.145249

Keywords:

Ivermectin, R 2 B strain, Haemagglutination test

Abstract

Antiviral activity of ivermectin was examined against R2B strain of Newcastle disease virus in 9 - day old embryonated chicken eggs. Five distinct concentrations (500, 250, 100, 50, 10 µg/mL) of ivermectin were used in the study. Haemagglutination test was performed to determine the antiviral activity of ivermectin by using chicken RBC. The results revealed that ivermectin can exert a significant antiviral activity against Newcastle disease virus at higher concentrations (500, 250 and 100 µg/ml) but with cytotoxic effects. On the contrary a moderate to weak antiviral activity without cytotoxicity was demonstrated at lower concentrations (50, 10 µg/ml).

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