Effect of SilK Fibroin loaded silver nanopartiCles gel on wound healing in three labrador dogs

T.S. Premavathy; Mohamed Shafiuzama; R. Siva Shankar; Mala Shammi; S. Hemalatha

doi:10.56093/ijvasr.v46i6.145831

Authors

T.S. Premavathy PG Scholar, Department of Veterinary Surgery and Radiology, Madras Veterinary College, Chennai-600007
Mohamed Shafiuzama Professor, Department of Veterinary Surgery and Radiology, Madras Veterinary College, Chennai - 600 007.
R. Siva Shankar Assistant Professor, Department of Veterinary Surgery and Radiology, Madras Veterinary College, Chennai-600 007
Mala Shammi Professor, Department of Veterinary Surgery and Radiology, Madras Veterinary College, Chennai - 600 007.
S. Hemalatha Professor, Department of Veterinary Pathology, Madras Veterinary College, TANUVAS, Chennai- 600 007

https://doi.org/10.56093/ijvasr.v46i6.145831

Keywords:

Dog, Chronic non-healing wound,, Silk fibroin loaded silver nanoparticle

Abstract

Wound repair was a complex process requiring coordination of cascade of cellular responses to injury including inflammation, epithelialization, proliferation, angiogenesis and remodelling (Barrientoset al. 2008). A major drawback in conventional dressing materials, mainly composed of gauze, is the adherence between the fibers of the gauze materials and the tissue. Separation between the dressing material and the tissue becomes very difficult (Lin et al., 2000). In large wound cases if required donor site is not available, biomaterials like synthetic ornatural polymers and their composites can be used for temporary closure of wounds (Babuet al., 1996). Fibroin protein was known for wound dressing by regulating exudates of wound providing moist environment facilitated re-epithelialization, re-modelling of connective tissues and collagenisation (Teramotoet al. 2008). This study is done to assess the clinical outcome of silk fibroin loaded silver nanoparticle gel on wound healing in threeLabrador retriever dogs.

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