IN VITRO ANTIMICROBIAL EFFECT OF OXYCLOZANIDE ANTHELMINTIC AGAINST DRUG RESISTANT STAPHYLOCOCCUS AUREUS ISOLATED FROM BOVINE MASTITIS MILK
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Authors
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A. Elamaran
Assistant Professor, Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Orathanadu – 614 625,
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P. Senthil Kumar
Professor and Head, Department of Veterinary Pharmacology and Toxicology, Veterinary, College and Research Institute, Tirunelveli – 627 358
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V. Ranganathan
Professor and Head, Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Orathanadu – 614 625
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K. Kannan
Assistant Professor, Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Orathanadu – 614 625,
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T. Ramasamy
Assistant Professor, Department of Veterinary Pharmacology and Toxicology, Madras Veterinary College, Chennai – 600 007
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C.M. Jaikanth
Assistant Professor, Department of Veterinary Pharmacology and Toxicology, Madras Veterinary College, Chennai – 600 007
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S. Senthil Kumar
Professor and Head, Department of Veterinary Surgery and Radiology, Veterinary College and Research Institute, Salem – 636 101
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J. Vijay Anand
Assistant Professor, Department of Animal Biotechnology, Madras Veterinary College, Chennai – 600 007
Keywords:
Bovine Mastitis, Oxyclozaninde, MRSA, In vitro, MICAbstract
This study investigated oxyclozanide, a salicylanilide anthelmintic, as an alternative treatment for Methicillin-resistant Staphylococcus aureus (MRSA) in bovine mastitis. With conventional treatments facing challenges due to antibiotic resistance, oxyclozanide demonstrated promising in vitro antimicrobial effect against MRSA isolates. The minimal inhibitory concentration (MIC) ranged from 0.5 to 1.0 μg/ml, indicating its efficacy. Oxyclozanide’s mechanism involved disrupting the transmembrane structure of bacteria, presenting a potential strategy against MRSA. This suggested the repurposing of oxyclozanide as a viable option for combating MRSA in bovine mastitis, prompting further investigation into its precise mechanism and therapeutic potential.
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