MOLECULAR CONFIRMATION AND THERAPEUTIC RESPONSE TO MINOCYCLINE IN DOGS WITH CANINE MONOCYTIC EHRLICHIOSIS

Rakesh Dangi; Nidhi S. Choudhary; Prashant Patil; Yadagiri Aruna; Mansi Awase

doi:10.56093/ijvasr.v55i6.185497

Authors

Rakesh Dangi Veterinary Assistant Surgeon, Department of Animal Husbandry and Dairying, Govt. of Madhya Pradesh
Nidhi S. Choudhary Professor, Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Mhow, NDVSU, Madhya Pradesh
Prashant Patil PG Scholar, Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Mhow, NDVSU, Madhya Pradesh
Yadagiri Aruna Assistant Professor, Department of Veterinary Medicine, College of Veterinary Science, Garvidi
Mansi Awase PG Scholar, Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, Mhow, NDVSU, Madhya Pradesh

https://doi.org/10.56093/ijvasr.v55i6.185497

Keywords:

Ehrlichia canis, minocycline, PCR

Abstract

Canine monocytic ehrlichiosis (CME), caused by Ehrlichia canis, is a tick-borne disease associated with multisystemic involvement and hematobiochemical alterations. The present study evaluated diagnosis, therapeutic response and clinical outcome in eight infected dogs. Diagnosis was established by peripheral blood smear examination and confirmed by polymerase chain reaction. All dogs received minocycline at 10 mg/kg intravenously every 12 h for 4 days, followed by oral administration at the same dose for 24 days. Supportive therapy included silymarin, platelet-enhancing agents and additional treatment as required. Clinical and hematobiochemical improvements occurred, with complete recovery in all dogs by day 28.

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References

Abhijith, S., Kalam, A.A. and Apoorva, H. (2026). Canine monocytic ehrlichiosis: pathogenesis, diagnosis, treatment and clinical outcomes. Indian Journal of Veterinary and Animal Sciences Research, 55(1): 17–33.

Aziz, M.U., Hussain, S., Song, B., Ghauri, H.N., Zeb, J. and Sparagano, O.A. (2022). Ehrlichiosis in dogs: a comprehensive review about the pathogen and its vectors with emphasis on south and east asian countries. Veterinary Sciences, 10(1): 21.

Espino-Solis, G.P., Flores-Lira, E.A., Barreras-Serrano,A., García-Reynoso, I.C., De La Mora Covarrubias, A., Vega, F.J. and Escarcega-Avila, A. (2023). Clinical and pathological factors associated with Ehrlichia canis in companion dogs. The Journal of Infection in Developing Countries, 17(11): 1598–1605.

Jeevitha, M., Tamileniyan, E., Karthika, K., Latchumikanthan, A., Veeraselvam, M. and Saravanan, M. (2024). Canine ehrlichiosis and triple therapy: a case report. Indian Journal of Veterinary and Animal Sciences Researc, 53(2): 94-98.

Jenkins, S., Ketzis, J.K., Dundas, J. and Scorpio, D. (2018). Efficacy of minocycline in naturally occurring nonacute Ehrlichia canis infection in dogs. Journal of Veterinary Internal Medicine, 32(1): 217-221.

Kabir, A., Chouhan, C.S., Habib, T., Hossain, M.Z., Raihan, A., Yeasmin, F., Siddique, M.P., Rahman, A.K.M.A., Nahar, A., Rahman, M.S. and Ehsan, M.A. (2024). Epidemiology of canine ehrlichiosis and molecular characterization of Erhlichia canis in Bangladeshi pet dogs. Plos One, 19(12): 0314729.

Kukreti, K., Pandey, L., Das, M., Rastogi, A., Dubey, R. and Sharma, P. (2018). Prevalence of canine monocytic ehrlichiosis in canine population across India. PubMed, 73(2): 87–93.

Murphy, G.L., Ewing, S., Whitworth, L.C., Fox, J. and Kocan, A. (1998). A molecular and serologic survey of Ehrlichia canis, E. chaffeensis and E. ewingii in dogs and ticks from Oklahoma. Veterinary Parasitology, 79(4): 325–339.

Palerme, J.S. (2026). Ehrlichiosis in dogs. MSD Veterinary Manual. Merck & Co., Inc., Kenilworth, NJ, USA.

Pillco, P., Calderon-Ruiz, S.W., Pinares, R. and Pizarro, D.M. (2025). Comparative evaluation of four drugs on hematology and recovery time of canine monocytic Ehrlichiosis. Iraqi Journal of Veterinary Sciences, 39(2): 253–260.

Singh, R., Bhardwaj, R.K. and Gupta, A.K. (2018). Prevalence and molecular characterization of Ehrlichia canis in dogs of Jammu region. Journal of Animal Research, 8(5): 939-943.

Snedecor, G.W. and Cochran, W.G. (1994). Statistical Methods, 8th Edn., Iowa State University Press. U.S.A.