Reproductive Toxicity Induced by 5-Fluorouracil (5-FU) and the Potential Ameliorative Effects of Naringin in -28 Days Experimental Study in Wistar Rats


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Authors

  • Sravathi Vemula Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad, Telangana, India
  • Jeevanalatha Mylaram Department of Veterinary Pathology, College of Veterinary Science, Mamnoor-Warangal, Telangana, India
  • Swathi Bora Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad, Telangana, India
  • Nagarjuna Gandham Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad, Telangana, India
  • Mounika Kamishetti Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad, Telangana, India
  • Durga Veera Hanuman Donga Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad, Telangana, India
  • Bhaskar Debbarma Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad, Telangana, India

https://doi.org/10.62757/IVA.2024.101.1.24-27

Keywords:

Naringinin, testicular toxicity and inflammation

Abstract

This study evaluates the potential ameliorative effects of Naringenin (NG) on testicular function in a 5-Fluorouracil (5-FU) induced testicular toxicity model. Male rats were divided into control, 5-FU treated, NG treated and NG + 5-FU combination groups with 6 animals each. Hormonal assays revealed a significant decrease in 5-FU treated group. Furthermore, pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) exhibited a marked increase in the 5-FU group, which was significantly attenuated by decrease pro-inflammatory levels in NG + 5-FU combination group. Anti-inflammatory cytokine (IL-10) levels significantly decreased in 5-FU group but were notably restored with NG treatment along with hormone levels by mitigating chemotherapy-induced testicular damage.

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References

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Submitted

2024-01-19

Published

2024-01-19 — Updated on 2025-12-28

Versions

Issue

Vol. 101 No. 01 (2024): January, 2024

Section

Articles

How to Cite

Sravathi Vemula, Jeevanalatha Mylaram, Swathi Bora, Nagarjuna Gandham, Mounika Kamishetti, Durga Veera Hanuman Donga, & Bhaskar Debbarma. (2025). Reproductive Toxicity Induced by 5-Fluorouracil (5-FU) and the Potential Ameliorative Effects of Naringin in -28 Days Experimental Study in Wistar Rats. The Indian Veterinary Journal, 101(01), 24-27. https://doi.org/10.62757/IVA.2024.101.1.24-27 (Original work published 2024)