Effect of Sapodilla (Manilkara zapota L.) Leaves Extract on the Lipid Levels of Diabetic Mice Induced with Alloxan
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Authors
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Cinta Atsa Mahesa Rani
Student, School of Health and Life Sciences, Universitas Airlangga
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Tridiganita Intan Solikhah
Division of Veterinary Clinic, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Indonesia
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Boedi Setiawan
Division of Veterinary Clinic, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Indonesia
Keywords:
Alloxan, Diabetes, Lipid, SapodillaAbstract
Sapodilla leaves extract has hypocholesterolemic and high antioxidant activity with potential to protect the body from ROS effect. This study used 25 male mice which were divided into 5 groups. The groups consisted of diabetic mice control, diabetic mice treated with pioglitazone 20mg/kg, normal mice control, diabetic mice treated with sapodilla leaves extract at 70mg/kg and 140mg/kg. The results of the study showed that 14 days administration of sapodilla leaves extract at 70 mg/kg and 140 mg/kg decreased the TG, LDL, and TC, while at 140 mg/kg, sapodilla leaf extract increased the HDL level.
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