Effect of Sapodilla (ManilkarazapotaL.) Leaves Extract on Pancreasof AlloxanInduced Mice: A Histopathological Study
220 / 26
Authors
-
Mela Septiani
Student, School of Health and Life Sciences, Universitas Airlangga
-
Tridiganita Intan Solikhah
Faculty of Health, Medicine, and Life Science, Universitas Airlangga, Indonesia
-
Boedi Setiawan
Division of Veterinary Clinic, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Indonesia
Keywords:
Diabetes, Manilkara zapota, HistopathologyAbstract
Diabetes mellitusis a metabolic disorder in the form of high levels of glucose in the blood. This study was conducted to determine the effect of Manilkara zapota leaf extract (MZLE) on alloxan-induced mice. 25 male mice ± 3 months, 25-35 g, treated with P1 (MZLE 140 mg/kg), P2 (MZLE 70mg/kg), K+ (Pioglitazone 20 mg/kg), P0 (normal control) and K- (diabetescontrol). Pancreas was taken on day 14 after being given therapy. Data analysis by Kruskal Wallis and MannWhitney. MZLE 140 mg/kg showed that the highest pancreatic protection compared to MZLE 70 mg/kg and pioglitazone 20 mg/kg.
Downloads
References
Abdul-Hamid M, and Moustafa N (2013) Protective effect of curcumin on histopathology and ultrastructure of pancreas in the alloxan treated rats for induction of diabetes. J Basic Appl Zool.66(4): 169-179.
Charbonneau MS, and Capoccia KL (2022) Pioglitazone: Reviewed and Renewed.ADCES Pract.10(4): 30-35.
Cole JB, and Florez JC (2020) Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol.16(7): 377-390.
Ghorbani A (2017) Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 96: 305-312.
Ghosh S, Besra SE, Roy K, and Gupta JK (2015) Pharmacological effects of methanolic extract of Swietenia mahagoni Jacq (meliaceae) seeds. Int J Green Pharm.3(3): 206-210.
Karle PP, Dhawale SC, and Navghare, V.V., (2022) Amelioration of diabetes and its complications by manilkara zapota (l) p. Royen fruit peel extract and its fractions in alloxan and stz-Na induced diabetes in wistar rats. J Diabetes Metab Disord.21(1): 493-510.
Khairullah AR, Solikhah TI, and Ansori ANM (2020) A review of an important medicinal plant : Alpinia galanga (L.) willd. Syst Rev Pharm.11(10):387-395.
Solikhah TI, and Solikhah GP (2021) Effect of Muntingiacalabura L. leaf extract on blood glucose levels and body weight of alloxan-induced diabetic mice. Pharmacogn J.13(6): 1450-1455.
Solikhah TI, Setiawan B, and Ismukada DR. (2020) Antidiabetic activity of papaya leaf extract (Carica Papaya L.) isolated with maceration method in alloxan-induces diabetic mice. Syst Rev Pharm. 11(9):774–778.
Solikhah TI, Rani CA, Septiani M, Putra YA, Rachmah Q, Solikhah GP, Agustono B, Yunita, MN, and Purnama MT. (2022) Antidiabetic of hylocereuspolyrhizus peel ethanolic extract on alloxan induced diabetic mice. Iraqi J Vet Sci.36(3): 797-802.
Solikhah TI, Wijaya TA, Pavita DA, Miftakhurrozaq RK, Raharjo HM, Yunita MN, and Fikri F (2023) The Effect of Sapodilla Leaf Extract (Manilkara zapota L.) on Lipid Profiles of Alloxan-Induced Diabetic Mice. Pharmacogn J. 15(2): 286-289.
Downloads
Submitted
Published
Versions
- 2026-02-04 (2)
- 2025-12-13 (1)