Antimotility, anti-diarrheal, and antibacterial activities of hydroalcoholic extract of Cordia dichotoma leaves in Wistar rat
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Authors
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Rahul Dev
Division of Pharmacology and Toxicology, Faculty of Veterinary Science and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R. S. Pura, Jammu-181102, Jammu and Kashmir, India.
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Nrip Kishore Pankaj
Division of Pharmacology and Toxicology, Faculty of Veterinary Science and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R. S. Pura, Jammu-181102, Jammu and Kashmir, India.
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Lenesha Manhas
Division of Pharmacology and Toxicology, Faculty of Veterinary Science and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R. S. Pura, Jammu-181102, Jammu and Kashmir, India.
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Pawan Kr. Verma
Division of Pharmacology and Toxicology, Faculty of Veterinary Science and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R. S. Pura, Jammu-181102, Jammu and Kashmir, India.
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Amruthanand
Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
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Thakur Uttam Singh
Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
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Neelesh Sharma
Division of Veterinary Medicine, Faculty of Veterinary Science and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R.S. Pura, Jammu-181102, Jammu and Kashmir, India.
Keywords:
CD, anti-diarrheal, Cordia dichotoma, DRCAbstract
activities of the hydro-alcoholic extract of Cordia dichotoma leaves (CD). The CD was screened on the dose-response curve (DRC) of acetylcholine (Ach) over isolated ileum. CD was evaluated in the model (n=6), including Group I received 0.1% Carboxymethyl cellulose@1ml/100g b.wt., Group II, Loperamide@2.5mg/Kg b.wt., Group III, IV, and V, had CD@125, 250, and 500mg/Kg respectively. The CD was also screened for its antibacterial effects over Escherichia coli and Staphylococcus aureus.CD shifted the DRC of Ach towards the right, showed a dose-dependent decline in diarrhea, and had antibacterial activities over E. coli.
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