HISTOPATHOLOGICAL CHANGES IN GILL, KIDNEY AND LIVER OF AN ESTUA E MULLET, LIZA PARSIA, INDUCED BY SUBLETHAL EXPOSURE TO DDT
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Authors
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A. K. PANDEY
Central Marine Fisheries Research Institute,
Post Bag No. 1603, Cochin - 682 014
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SHYAMLAL SHYAMLAL
Central Marine Fisheries Research Institute,
Post Bag No. 1603, Cochin - 682 014
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M. PEER MOHAMED
Central Marine Fisheries Research Institute,
Post Bag No. 1603, Cochin - 682 014
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K. C. GEORGE
Central Marine Fisheries Research Institute,
Post Bag No. 1603, Cochin - 682 014
Abstract
Liza parsia were exposed to sublethal (0.02 ppm) concentration of DDT for 15 days. The gill
responded initially with copious secretion of mucus, oedematous separation of epithelial cells
from the basement membrane and fusion of secondary gill lamellae. Hyperplasia of the cells
lining primary gill lamellae and lamellar telangiectases (or aneurysms) were frequently seen
after day 10 of exposure. Kidney exhibited hypertrophy of the epithelial cells lining proximal
convoluted tubules which was followed by shrinkage in glomerular tufts, increase in Bowman's
space, appearance of amorphous eosinophilic materials in the lumina of the tubules and focal
necrosis on day 10 of the treatment. Hyaline droplets and casts were also encountered in the
epithelial cells and lumina of the proximal tubules. Liver revealed an intitial dilation of
canaliculi and increased secretion of bile. Thereafter, the displacement of nuclei towards
periphery of the hepatocytes, disorganization of blood sinusoids, pyknotic changes in nuclei,
cytolysis and vacuolation as well as focal necrosis were noticed after day 10 of the intoxication.
