Antibacterial of Flavonoids from Myrmecodia pendens (Sarang Semut) Against Streptococcus mutans ATCC 25175
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Authors
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yuti malinda
Universitas Padjadjaran
Keywords:
Myrmecodia pendans, flavonoid, Streptococcus mutansAbstract
Dental caries is the most common disease in world. Starts with demineralization of the tooth surface which caused by many kinds of bacteria, especially Streptococcus mutans (S. mutans). S. mutans is sensitive to chlorheksidine, but the side effects are tooth stain and taste alteration. Therefore, herbal ingredient is considered more beneficial than chlorheksidine to eliminate the side effect. Myrmecodia pendans known as Sarang Semut used as a traditional herbal medicine in Papua island and contains flavonoid.
Antibacterial of Flavonoid A and B sarang semut to S. mutans was explored by obtaining the value of minimal inhibition concentration (MIC) using microdilution method; and minimal bactericidal concentration (MBC) using agar dilution method. Mann Whitney statistical comparison test was performed to calculate the antibacterial effects of two flavonoids.
The MIC and MBC value for Flavonoid A in order are 312.5 and 1250 ppm, whereas Flavonoid B are 156.25 and 2500 ppm to S. mutans ATCC 25175. Mann Whitney test (p-value= 0.817) presented equal antibacterial effect between Flavonoid A and B Sarang Semut.
Flavonoid A and B have an antibacterial effect. Moreover, there was no significant difference between antibacterial of Flavonoid A and B Sarang Semut to S. mutans ATCC 25175
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