Anti-inflammatory activity of methanolic extracts of Pseudarthria viscida and Uraria picta against carrageenan induced paw edema in albino rat
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Abstract
Pseudarthria viscida and Uraria picta are the major constituents of Ayurvedic Dashmool formulation. They belong to the family Fabaceae. Both plants are reported for their important biological activities in indigenous system of medicine. This study was carried out to evaluate anti-inflammatory activities of the whole plant methanolic extract of P. viscida and U. picta on carrageenan induced paw edema in albino rat. The methanolic extract of P. viscida and U. picta were administered orally at dose levels of 200 and 400 mg/kg body weight. Level of inhibition by the extracts was compared with Indomethacin standard reference drug. However P. viscida had higher inhibitory activity compare to U. picta. This signifies that methanolic extract from P. viscida is more potent than U. picta in the treatment of paw edema in albino rat. Present study provides information on pharmacological evidences that Pseudarthria viscida and Uraria picta could be used as agent against inflammation. Further study for characterization, identification of active compound and mechanism of action responsible for said activity is ongoing.Submitted
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