Leaching and Residual Kinetics of Chloramphenicol Incorporated Medicated Feed Treated to Juvenile Black Tiger Shrimp Penaeus monodon

Abstract

The leaching rate of chloramphenicol (CAP) incorporated medicated feed after immersion in water was high during the first 10 min. About 30% loss of CAP from the medicated feed was observed after 2 h of immersion. The leaching rate was not uniform in the period of 10 h experiments. Juvenile black tiger shrimp Penaeus monodon fed for 7 days with recommended dose (50-100 mg/kg shrimp) of CAP were examined for residual accumulation and depletion. A higher residue of 7.10 mg/g shrimp tissue was found after 1 day of postdosing. This was estimated as 2.15% of the total CAP intake in the7 days of experimental period. By the 20th day following cessation of medicated feed treatment the CAP concentration was found below detectable limit.