Collagen Hydrogel as Bio Interactive dressing for wound healing

Abstract

In the present study, wound healing efficacy of the
hydrogel prepared from fish skin collagen was
evaluated in experimental full thickness wounds
using albino rat model. The study demonstrated that
within 2 weeks, the wound covered with gel were
completely filled with new epithelium without any
significant adverse reactions. The results clearly
suggest that the hydrogel enhances re-epithelialization
rather than a repair which was clear from the
histopathology and biochemical analysis. There is
significant increase in angiogenesis, collagen deposition,
hexosamine content, epithelialization and wound
contraction in hydrogel treated rats without inflammatory
cells compared to the control group, indicating
the tissue regeneration potential of fish collagen.