Physio-biochemical Response of Labeo rohita (Hamilton, 1822) fed with Antifungal Drug, Fluconazole

Abstract

An experiment was carried out to delineate the
biochemical responses in Labeo rohita fingerlings fed
with fluconazole (FLZ). There were twenty-four
treatments divided into four groups (Control, T1,
T2, and T3 fed with 0, 10, 20 and 30 mg FLZ
kg-1 body weight, respectively) and each group with
6 exposure times (0, 6, 12, 24, 48, and 96 h) in
triplicates. Biochemical parameters in plasma like
glutamate oxaloacetate transaminase (GOT),
glutamate pyruvate transaminase (GPT), alkaline
phosphatase (ALP), glucose, albumin, albumin
globulin ratio (A/G) were measured. Significant
increase (p<0.05) in the GOT, ALP, and decrease
(p<0.05) in glucose were observed in the treatment
groups as compared to control. However, homeostasis
was achieved by rohu within 48 h of administration.
Fish fingerlings treated with fluconazole at
higher doses exhibited marked changes in physiology.