Dietary Quercetin for Enhanced Broiler Performance- A Review
325 / 26
Keywords:
Antioxidant, Broiler chicken, Gut microbiota, Poultry feed additives, QuercetinAbstract
Quercetin, a naturally occurring flavonoid, has received attention for its potential benefits in chicken nutrition due to its antioxidant, anti-inflammatory, and gut-health-promoting qualities. This review summarizes current research on quercetin supplementation in broiler chickens, focusing on its implications on growth performance, immunological response, gut health, and meat quality. Quercetin has been shown in studies to improve body weight increase, feed conversion efficiency, and nutrient absorption while also reducing oxidative stress by upregulating antioxidant enzymes like superoxide dismutase and glutathione peroxidase. Furthermore, it aids immunological regulation by lowering inflammatory cytokines and increasing disease resistance. Quercetin also improves gut microbiota composition and shape, resulting in greater digestive health. Furthermore, it enhances meat quality by lowering lipid peroxidation, improving texture, and increasing shelf life. Findings indicate quercetin as a possible natural alternative to antibiotics in broiler diets, which aligns with the growing need for sustainable, antibiotic-free poultry production. However, additional research is needed to enhance its bioavailability, administration approaches, and long-term effects in commercial applications. Future research should focus on improving its bioavailability and determining its economic viability in large-scale commercial applications.
References
1. Abdel-Latif, M., Elbestawy, A., El-Far, A., Noreldin, A., Emam, M., Baty, R., Albadrani, G., Abdel-Daim, M. M., and Abd El-Hamid, H. S. 2021. Quercetin dietary supplementation advances growth performance, gut microbiota, and intestinal mRNA expression genes in broiler chickens. Animals. 11.
2. Abdelrahman, R. E., Khalaf, A. A., Elhady, M., Ibrahim, M., Hassanen, E. I., and Noshy, P. A. 2022. Antioxidant and antiapoptotic effects of quercetin against ochratoxin A-induced nephrotoxicity in broiler chickens. Environmental Toxicology and Pharmacology. 103982.
3. Abid, A. R., Areaaer, A., Hussein, M. A., Gatea, S. M., and Al-Nuaimi, J. 2019. Impact of different levels of quercetin on productive performance of broiler chickens (Ross-308). International Conference of Numerical Analysis and Applied Mathematics (ICNAAM 2019).
4. Agarwal, N., Kolba, N., Khen, N., Even, C., Turjeman, S., Koren, O., and Tako, E. 2022. Quinoa soluble fiber and quercetin alter the composition of the gut microbiome and improve brush border membrane morphology in vivo (Gallus gallus). Nutrients. 14.
5. Ahammad, G., and Kim, I. 2024. Effects of micellar quercetin supplementation on growth performance, nutrient digestibility, fecal microbiota, meat quality, and physiological status in broiler chickens. Animals. 14.
6. Algan, A. H., and Karatas, A. 2023. Preparation and characterization of quercetin-loaded polymeric nanoparticles. Macedonian Pharmaceutical Bulletin.
7. Al-Nasser, A. Y., El-Khalaifah, H., Abdelfattah-Hassan, A., Eldoumani, H., Khater, S., Arisha, A., Alugoju, P. H., D, K. V. K., and Periyasamy, L. 2018. Effect of short-term quercetin, caloric restriction, and combined treatment on age-related oxidative stress markers in the rat cerebral cortex. CNS and Neurological Disorders - Drug Targets. 17(2): 119-131.
8. Amevor, F. K., Cui, Z., Du, X., Ning, Z., Deng, X., Xu, D., Shu, G., Wu, Y., Cao, X., Shuo, W., Tian, Y., Li, D., Wang, Y., and Zhang, Y. 2022. Supplementation of dietary quercetin and vitamin E promotes the intestinal structure and immune barrier integrity in aged breeder hens. Frontiers in Immunology. 13.
9. Attia, Y., Ashour, E., Nagadi, S., Farag, M. R., Bovera, F., and Alagawany, M. 2023. Rice bran as an alternative feedstuff in broiler nutrition and impact of Liposorb® and vitamin E-Se on sustainability of performance, carcass traits, blood biochemistry, and antioxidant indices. Veterinary Sciences. 10.
10. Attia, Y., Hassan, R. A., Addeo, N. F., Bovera, F., Alhotan, R., Al-Qurashi, A. D., Al-Baadani, H., Al-Banoby, M. A., Khafaga, A., Eisenreich, W., Shehata, A., and Basiouni, S. 2023. Effects of Spirulina platensis and/or Allium sativum on antioxidant status, immune response, gut morphology, and intestinal Lactobacilli and Coliforms of heat-stressed broiler chicken. Veterinary Sciences. 10.
11. Azizi, M. N., Loh, T., Foo, H., Akit, H., Wan Ibrahim, I., and Yohanna, D. 2023. Brown and green seaweed antioxidant properties and effects on blood plasma antioxidant enzyme activities, hepatic antioxidant genes expression, blood plasma lipid profile, and meat quality in broiler chickens. Animals. 13.
12. Bellavite, P. 2023. Neuroprotective potentials of flavonoids: Experimental studies and mechanisms of action. Antioxidants. 12.
13. Benzertiha, A., Kierończyk, B., Rawski, M., Kołodziejski, P., Bryszak, M., and Józefiak, D. 2019. Insect oil as an alternative to palm oil and poultry fat in broiler chicken nutrition. Animals. 9.
14. Beski, S., Swick, R., and Iji, P. 2015. Specialized protein products in broiler chicken nutrition: A review. Animal Nutrition. 1: 47-53.
15. Brovarets’, O., and Hovorun, D. M. 2019. Conformational diversity of the quercetin molecule: A quantum-chemical view. Journal of Biomolecular Structure and Dynamics. 38: 2817-2836.
16. Bukowska, B., and Duchnowicz, P. 2022. Molecular mechanisms of action of selected substances involved in the reduction of benzo[a]pyrene-induced oxidative stress. Molecules. 27.
17. Chiu, Y.-J., Teng, Y.-S., Chen, C., Sun, Y.-C., Hsieh-Li, H., Chang, K.-H., and Lee-Chen, G. 2023. A neuroprotective action of quercetin and apigenin through inhibiting aggregation of Aβ and activation of TRKB signaling in a cellular experiment. Biomolecules & Therapeutics. 31: 285-297.
18. Delles, R., Xiong, Y., True, A. D., Ao, T., and Dawson, K. 2014. Dietary antioxidant supplementation enhances lipid and protein oxidative stability of chicken broiler meat through promotion of antioxidant enzyme activity. Poultry Science. 93: 1561-1570.
19. Divani, A., Bagherzadeh-Kasmani, F., and Mehri, M. 2018. Plantago ovata in broiler chicken nutrition: Performance, carcass criteria, intestinal morphology, immunity, and intestinal bacterial population. Journal of Animal Physiology and Animal Nutrition. 102: e353–e363.
20. Dong, Y., Lei, J., and Zhang, B. 2020. Effects of dietary quercetin on the antioxidative status and cecal microbiota in broiler chickens fed with oxidized oil. Poultry Science. 99: 4892–4903.
21. Dong, Y., Lei, J., Zhang, B., and Guo, Y. 2020. Effects of dietary quercetin on the antioxidative status and cecal microbiota in broiler chickens fed with oxidized oil. Poultry Science. 99: 4892-4903.
22. Duskaev, G., Kurilkina, M. Y., and Zavyalov, O. A. 2023. The effect of feeding quercetin on the productive qualities and blood parameters of broiler chickens. Veterinaria i Kormlenie. DOI: 10.30917/ATT-VK-1814-9588-2023-2-6.
23. Faluyi, O. B., Akintomide, A. A., and Onibi, G. 2020. Antimicrobial and antioxidant effects of red onion (Allium cepa) on unrefrigerated broiler chicken meat. Animal Research International. 17.
24. Farag, M., Moselhy, A., El-Mleeh, A., Aljuaydi, S. H., Ismail, T., Cerbo di, A., Crescenzo, G., and Abou-Zeid, S. M. 2021. Quercetin alleviates the immunotoxic impact mediated by oxidative stress and inflammation induced by doxorubicin exposure in rats. Antioxidants. 10(11): 1-12.
25. Ghimire, S., Wongkuna, S., Sankaranarayanan, R., Ryan, E., Bhat, G. J., and Scaria, J. 2021. Positive synergistic effects of quercetin and rice bran on human gut microbiota reduce Enterobacteriaceae family abundance and elevate propionate in a bioreactor model. Frontiers in Microbiology. 12.
26. Goliomytis, M., Tsoureki, D., Simitzis, P. E., Charismiadou, M. A., Hager-Theodorides, A. L., and Deligeorgis, S. G. 2014. The effects of quercetin dietary supplementation on broiler growth performance, meat quality, and oxidative stability. Poultry Science. 93(8): 1957-1962.
27. Gumus, R., and Gelen, S. 2023. Effects of dietary thyme and rosemary essential oils on performance parameters with lipid oxidation, water activity, pH, colour, and microbial quality of breast and drumstick meats in broiler chickens. Archives Animal Breeding. 66(1): 17-29.
28. Hussien, K., Ismail, Z., and Abdel-Wareth, A. 2021. Application of zinc oxide nanoparticles as a feed additive in broiler chicken nutrition under hot environmental conditions. SVU-International Journal of Agricultural Sciences.
29. Ibrahim, D., Al-Khalaifah, H., Abdelfattah-Hassan, A., Eldoumani, H., Khater, S., Arisha, A., Mohamed, S. A. M., Ismail, T., and Tolba, S. 2021. Promising role of growth hormone-boosting peptide in regulating the expression of muscle-specific genes and related microRNAs in broiler chickens. Animals. 11.
30. Ilyich, T., Veiko, A., Lapshina, E., and Zavodnik, I. 2018. Quercetin and its complex with cyclodextrin against oxidative damage of mitochondria and erythrocytes: Experimental results in vitro and quantum-chemical calculations. Biophysics. 63: 537-548.
31. Imam, S., Suryadi, U., and Hanafi, M. I. 2022. Physical quality of broiler chicken meat added with banana weevil enriched β-glucan from Saccharomyces cerevisiae in feed. Bantara Journal of Animal Science.
32. Jaber, F. A. 2023. Quercetin mitigates oxidative stress, inflammation, apoptosis, and histopathological alterations induced by chronic titanium dioxide nanoparticle exposure in the rat spleen. Microscopy and Microanalysis. 29(4): 1-12.
33. Janocha, A., Milczarek, A., Pietrusiak, D., and Łaski, K. 2021. Impact of milk thistle (Silybum marianum [L.] Gaertn.) seeds in broiler chicken diets on rearing results, carcass composition, and meat quality. Animals. 11.
34. Janocha, A., Milczarek, A., Pietrusiak, D., Łaski, K., and Saleh, M. 2022. Efficiency of soybean products in broiler chicken nutrition. Animals. 12.
35. Jurašeková, Z., Domingo, C., García-Ramos, J., and Sánchez Cortés, S. 2014. Effect of pH on the chemical modification of quercetin and structurally related flavonoids characterized by optical (UV-visible and Raman) spectroscopy. Physical Chemistry, Chemical Physics - PCCP. 16: 12802-12811.
36. Kim, M. K., Jung, H., Yoon, C., Ko, J., Chun, H., Kim, T. K., Kwon, M., Lee, S., Koh, K. S., Rhee, B., and Park, J. H. 2010. EGCG and quercetin protected INS-1 cells in oxidative stress via different mechanisms. Frontiers in Bioscience. 2: 810-817.
37. Liu, C.-M., Zheng, G.-H., Cheng, C., and Sun, J.-M. 2013. Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1/JNK and PI3K/Akt pathway. Free Radical Research. 47: 192-201.
38. Liu, L., Liu, Y., Cheng, X., and Qiao, X. 2021. The alleviative effects of quercetin on cadmium-induced necroptosis via inhibition ROS/iNOS/NF-κB pathway in the chicken brain. Biological Trace Element Research. 199: 1584-1594.
39. Maksymchuk, O., Shysh, A., and Kotliarova, A. 2023. Quercetin inhibits the expression of MYC and CYP2E1 and reduces oxidative stress in the myocardium of spontaneously hypertensive rats. Acta Biochimica Polonica. 70(1): 1-12.
40. Marcinčák, S., Klempová, T., Bartkovský, M., Marcinčáková, D., Zdolec, N., and Popelka, P. 2018. Effect of fungal solid-state fermented product in broiler chicken nutrition on quality and safety of produced breast meat. BioMed Research International. 2018.
41. Materska, M. 2008. Quercetin and its derivatives: chemical structure and bioactivity - a review. Polish Journal of Food and Nutrition Sciences. 58: 407-413.
42. McKay, T. B., Lyon, D., Sarker-Nag, A., Priyadarsini, S., Asara, J. M., and Karamichos, D. 2015. Quercetin attenuates lactate production and extracellular matrix secretion in keratoconus. Scientific Reports. 5(1): 9003.
43. Mohammadian, M., Moghaddam, A. D., Sharifan, A., Dabaghi, P., and Hadi, S. 2020. Nanocomplexes of whey protein fibrillar aggregates and quercetin as novel multi-functional biopolymeric ingredients: Interaction, chemical structure, and bio-functionality. Journal of the Iranian Chemical Society. 17: 2481-2492.
44. Moustafa, E. S., Alsanie, W. F., Gaber, A., Kamel, N., Alaqil, A., and Abbas, A. O. 2021. Blue-green algae (Spirulina platensis) alleviates the negative impact of heat stress on broiler production performance and redox status. Animals. 11(4): 1-12.
45. Obianwuna, U. E., Agbai Kalu, N., Wang, J., Zhang, H., Qi, G., Qiu, K., and Wu, S. 2023. Recent trends on mitigative effect of probiotics on oxidative-stress-induced gut dysfunction in broilers under necrotic enteritis challenge: A review. Antioxidants. 12(4): 911.
46. Olla, S., Siguri, C., Fais, A., Era, B., Fantini, M., and Di Petrillo, A. 2023. Inhibitory effect of quercetin on oxidative endogen enzymes: A focus on putative binding modes. International Journal of Molecular Sciences. 24.
47. Ozbek, N., Bali, E. B., and Karasu, C. 2015. Quercetin and hydroxytyrosol attenuates xanthine/xanthine oxidase-induced toxicity in H9c2 cardiomyocytes by regulation of oxidative stress and stress-sensitive signaling pathways. General Physiology and Biophysics. 34(4): 407-414.
48. Ozgen, S., Kılınç, Ö., and Selamoğlu, Z. 2016. Antioxidant activity of quercetin: A mechanistic review. Turkish Journal of Agriculture: Food Science and Technology. 4: 1134-1138.
49. Parmar, A., Patel, V., Patel, J. J., Usadadia, S., Rathwa, S., Prajapati, D., and Rathva, A. 2019. Quercetin, a health-promising phytoadditive for poultry production: Trends and advances. The Pharma Innovation Journal. 8: 68-74.
50. Patel, H., Patel, U., Modi, C., Ladumor, V. C., Makwana, C., and Rao, S. 2021. Pharmacokinetics of marbofloxacin following oral administration in piperine, quercetin alone, and both in combination pretreated broiler chickens. Indian Journal of Animal Research.
51. Rupasinghe, H., Ronalds, C. M., Rathgeber, B., and Robinson, R. 2010. Absorption and tissue distribution of dietary quercetin and quercetin glycosides of apple skin in broiler chickens. Journal of the Science of Food and Agriculture. 90(7): 1172-1178.
52. Saeed, M., Naveed, M., Arain, M., Arif, M., Abd El-Hack, M. A., Alagawany, M., Siyal, F. A., Soomro, R., and Sun, C. 2017. Quercetin: Nutritional and beneficial effects in poultry. World's Poultry Science Journal. 73: 355-364. https://doi.org/10.1017/S004393391700023X
53. Selle, P., Macelline, S., Chrystal, P., and Liu, S. 2023. A reappraisal of amino acids in broiler chicken nutrition. World's Poultry Science Journal. 79: 429-447.
54. Šeruga, M., and Tomac, I. 2017. Influence of chemical structure of some flavonols on their electrochemical behaviour. International Journal of Electrochemical Science. 12: 7616-7637.
55. Shanmugasundaram, D., and Roza, J. M. 2022. Assessment of anti-inflammatory and antioxidant activity of quercetin–rutin blend (SophorOx™) – an in vitro cell-based assay. Journal of Complementary and Integrative Medicine. 19: 637-644.
56. Shi, Z., Zhang, C., Lei, H., Chen, C., Cao, Z., Song, Y., Lu, Y., Zhang, L., and Zhang, Y. 2022. Structural insights into amelioration effects of quercetin and its glycoside derivatives on NAFLD in mice by modulating the gut microbiota and host metabolism. Journal of Agricultural and Food Chemistry.
57. Sierżant, K., Piksa, E., Konkol, D., Lewandowska, K., and Asghar, M. 2023. Performance and antioxidant traits of broiler chickens fed with diets containing rapeseed or flaxseed oil and optimized quercetin. Scientific Reports. 13.
58. Sun, L., Guo, L., Xu, G., Li, Z., Appiah, M. O., Yang, L., and Lu, W. 2022. Quercetin reduces inflammation and protects gut microbiota in broilers. Molecules. 27. https://doi.org/10.3390/molecules27103269
59. Tan, X., Xian, W., Li, X.-R., Chen, Y., Geng, J., Wang, Q., Gao, Q., Bi-Tang, E., Wang, H., and Kang, P. 2022. Mechanisms of quercetin against atrial fibrillation explored by network pharmacology combined with molecular docking and experimental validation. Scientific Reports. 12.
60. Tompkins, Y. H., Teng, P., Pazdro, R., and Kim, W. K. 2022. Long bone mineral loss, bone microstructural changes, and oxidative stress after Eimeria challenge in broilers. Frontiers in Physiology. 13: 945740.
61. Tyagi, S., Saxena, S., Srivastava, P., Sharma, T., Kundu, N., Kaur, S., and Shankaraswamy, J. 2020. Screening the binding potential of quercetin with parallel, antiparallel, and mixed G-quadruplexes of human telomere and cancer proto-oncogenes using molecular docking approach. SN Applied Sciences. 2.
62. Ugwuoke, H. C., Ogwuegbu, M., Edeh, H., Odonugo, M. O., Ani, A. O., and Onu, E. O. 2024. Effect of dietary quercetin on growth performance of broiler chickens. Nigerian Journal of Animal Production.
63. Veiko, A., Ilyich, T., Lapshina, E., Buko, V., and Zavodnik, I. 2018. Quantum-chemical modeling of the electronic structure of quercetin and inhibition by quercetin and quercetin–hydroxypropyl-β-cyclodextrin complex of lipid peroxidation in mitochondria and red blood cells of rats. Proceedings of the National Academy of Sciences of Belarus Biological Series.
64. Vinnarasi, S., Radhika, R., Vijayakumar, S., and Shankar, R. 2020. Structural insights into the anti-cancer activity of quercetin on G-tetrad, mixed G-tetrad, and G-quadruplex DNA using quantum chemical and molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics. 38: 317-339.
65. Walk, C., Romero, L., and Cowieson, A. 2021. Towards a digestible calcium system for broiler chicken nutrition: A review and recommendations for the future. Animal Feed Science and Technology.
66. Wang, M., Wang, B., Zhou, S., Liu, J., Lu, H., Wu, H., Ding, M., Li, Y., and Xu, W. 2022. Quercetin ameliorates chicken quality by activating the PI3K/PKB/AMPK signaling pathway in broilers. Frontiers in Veterinary Science. 9.
67. Yuan, K., Zhu, Q., Lu, Q., Jiang, H., Zhu, M., Li, X., and Xu, A. 2020. Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities. The Journal of Nutritional Biochemistry. 84: 108454.
68. Zavialov, O. A., Duskaev, G. K., and Kurilkina, M. Ya. 2023. Influence of biologically active additives of natural origin on the mineral composition of edible parts of the body of broiler chickens. Veterinary Science and Feeding. DOI: 10.30917/ATT-VK-1814-9588-2023-1-8, 1: 34-38.
Downloads
Submitted
Published
Issue
Section
License
Copyright remains with the society and author jointly. However, material can be used for research, teaching and to achieve goals of the society.