Changes in serum proteins and immune response in oreochromis mossambicus induced by aflatoxin B1


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Authors

  • Sherly Zacharia Central Marine Fisheries Research Institute, Cochin - 682 014, India
  • P C Thomas Central Marine Fisheries Research Institute, Cochin - 682 014, India
  • M P Paulton Central Marine Fisheries Research Institute, Cochin - 682 014, India

Abstract

Studies were conducted to evaluate the molecular changes induced by aflatoxin, the most frequently encountered dietary carcinogen in Oreochromis
mossambicus. Three sub-lethal test doses of aflatoxin B1 incorporated in feed (1.5, 5.0 and 15.0mg/kg feed) were given to the fishes for a period of 30 days and the changes in serum protein profile were resolved through SDS PAGE at regular intervals. Similarly, the changes in immune responses were also studied. The study revealed significant changes in both protein profile and immune response in the experimental fishes compared to the control, indicating that the toxin exerts its effect even at sublethal levels

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Author Biographies

  • Sherly Zacharia, Central Marine Fisheries Research Institute, Cochin - 682 014, India
    Central Marine Fisheries Research Institute, Cochin - 682 014, India
  • P C Thomas, Central Marine Fisheries Research Institute, Cochin - 682 014, India
    Central Marine Fisheries Research Institute, Cochin - 682 014, India
  • M P Paulton, Central Marine Fisheries Research Institute, Cochin - 682 014, India
    Central Marine Fisheries Research Institute, Cochin - 682 014, India

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Issue

Vol. 50 No. 4 (2003)

Section

Articles

License

The copyright of the articles published in Indian Journal of Fisheries vests with the Indian Council of Agricultural Research, who has the right to enter into any agreement with any organization in India or abroad engaged in reprography, photocopying, storage and dissemination of information contained in these journals. The Council has no objection in using the material, provided the information is being utilized for academic purpose but not for commercial use. Due credit line should be given to the ICAR where information will be utilized.

How to Cite

Zacharia, S., Thomas, P. C., & Paulton, M. P. (2011). Changes in serum proteins and immune response in oreochromis mossambicus induced by aflatoxin B1. Indian Journal of Fisheries, 50(4), 421-426. https://epubs.icar.org.in/index.php/IJF/article/view/7656