Suppression in haemolytic activities and specific antibody response of sera of the Indian major carps treated with malathion


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Authors

  • Kalpana Dash Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar-751 002, India
  • A K Pandey Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar-751 002, India
  • S Ayyappan Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar-751 002, India

Abstract

The present study describes the natural immune reaction of sera of the Indian major
carps, Catla catla, Laheo rohita and Cirrhinus mrigala, with special reference to
complement activation in normal as well as malathion-treated groups. Activation
of complement system of these fishes was found to be mainly through the alternative
pathway because level of the classical pathway (CHj^) -mediated killing of fishes was
very low in all the groups (range 2-4 units/ml). Furthermore, the alternative pathway
activation of fish sera (APCHg(,) is quite higher (30-40 units/ml) in all the groups
of major carps indicating that complement-mediated protection was operated mainly
through alternative pathway in these fishes while in higher vertebrates, the major
pathway of complement activation is through classical components. Exposure of the
Indian major carps to the two doses (0.25 and 3.00 ppm) of malathion significantly
suppressed their natural immunity through complement cascade. Further, malathion
treatment also reduces the specific antibody titre against soluble antigen (bovine
serum albumin, BSA) whereas it has no effect on the natural haemagglutinin titre
of these fish sera against rabbit erythroc3rtes (RaRBCs).

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Author Biographies

  • Kalpana Dash, Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar-751 002, India
    Central Institute of Freshwater Aquaculture, Kausalyaganga,
    Bhubaneswar-751 002, India
  • A K Pandey, Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar-751 002, India
    Central Institute of Freshwater Aquaculture, Kausalyaganga,
    Bhubaneswar-751 002, India
  • S Ayyappan, Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar-751 002, India
    Central Institute of Freshwater Aquaculture, Kausalyaganga,
    Bhubaneswar-751 002, India

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Issue

Vol. 47 No. 1 (2000)

Section

Note

License

The copyright of the articles published in Indian Journal of Fisheries vests with the Indian Council of Agricultural Research, who has the right to enter into any agreement with any organization in India or abroad engaged in reprography, photocopying, storage and dissemination of information contained in these journals. The Council has no objection in using the material, provided the information is being utilized for academic purpose but not for commercial use. Due credit line should be given to the ICAR where information will be utilized.

How to Cite

Dash, K., Pandey, A. K., & Ayyappan, S. (2011). Suppression in haemolytic activities and specific antibody response of sera of the Indian major carps treated with malathion. Indian Journal of Fisheries, 47(1), 71-76. https://epubs.icar.org.in/index.php/IJF/article/view/8574