EFFECT OF CURCUMIN AND NANOCURCUMIN ON HEAMATO BIOCHEMICAL PARAMETERS IN DALTON’S ASCITES LYMPHOMA IN MICE
Abstract views: 30
/ 
PDF downloads: 16
Authors
-
P. Krishnaveni
Postgraduate scholar, Department of Veterinary Pathology, Madras Veterinary College, TANUVAS
-
M. Thangapandiyan
Assistant Professor, Veterinary Clinical Complex, Veterinary College and Research Institute, TANUVAS, Udumalpet
-
P. Raja
Assistant Professor, Department of Animal Biotechnology, Madras Veterinary College, TANUVAS
-
G.V.S Rao
Professor and Head, Department of Veterinary Pathology, Madras Veterinary College, TANUVAS
Keywords:
Curcumin, Dalton’s Ascites Lymphoma, Solid lipid nanocurcuminAbstract
Curcumin derived from curcuma longa has been reported for its anti-cancer activity, but low bioavailability limits the therapeutic potential of curcumin. In this study curcumin and solid lipid nanocurcumin were tested for its therapeutic use and methotrexate was used as the standard drug. Methotrexate at a dose rate of 3.5mg/kg bodyweight and curcumin and nanocurcumin at a dose rate of 100 and 50 mg/kg bodyweight were evaluated in Dalton’s Ascites Lymphoma-bearing mice by assessing various hematobiochemical parameters. Hematological parameters were estimated using auto hematology analyzer and biochemical parameters with automatic serum biochemical analyzer. Dalton’s Ascites Lymphoma-bearing mice showed reduction in RBC count and amount of Hb and increased leukocyte count with neutrophilia in comparison with normal control group. The tumor control group also showed elevated levels of ALT, AST and ALP while albumin and total protein levels decreased in serum. Treatment with curcumin and nanocurcumin showed significant increase in RBC and Hb count as well as decrease in WBC count. There was a significant decrease ALT, AST and ALP and increase in albumin and total protein levels. Precisely curcumin and nanocurcumin showed significant influence in the restoration of various hematobiochemical parameters.
Downloads
References
Augustine, B.B., Dash, S., Lahkar, M., Sarma, U., Samudrala, P. K. and Thomas, J.M. (2014). Leucas aspera inhibits the Dalton's Ascitic Lymphoma in Swiss albino mice: A preliminary study exploring possible mechanism of action. Pharmacognosy Magazine,10 (38): 118-124
Danduga, R.C.S.R., Kola, P. K. and Matli, B., (2020). Anticancer activity of curcumin alone and in combination with piperine in Dalton lymphoma ascites bearing mice. Indian journal of Experimental Biology, 48:181-189
Dhamija, I., Kumar N., Manjula, S.N., Parihar, V., Setty, M.M. and Pai, K.S. (2011). Preliminary evaluation of in vitro cytotoxicity and in vivo antitumor activity of Premnaherbacea Roxb.in Ehrlich ascites carcinoma model and Dalton’s lymphoma ascites model. Experimental Toxicologic Pathology, 65(3): 235-242.
Dhamija, I., Kumar, N., Manjula, S.N., Parihar, V., Setty, M.M. and Pai, K.S.R., (2013). Preliminary evaluation of in vitro cytotoxicity and in vivo antitumor activity of Premna herbacea Roxb. in Ehrlich ascites carcinoma model and Dalton's lymphoma ascites model. Experimental and Toxicologic Pathology, 65(3): 235-242.
Gaze, D.C., (2007). The role of existing and novel cardiac biomarkers for cardio-protection.Current Opinion in Investigational Drugs, 8 (9): 711–717.
Loganayaki, N. and Manian, S. (2012). Antitumor activity of the methanolic extract of Ammannia baccifera L. against Dalton's ascites lymphoma induced ascitic and solid tumors in mice. Journal of Ethnopharmacology, 142(1): 305-309.
Manjula S.N., Kenganora, M., Parihar V.K., Kumar S., Nayak P.G., Kumar N., RanganathPai, K.S. and Rao, C.M. (2010). Antitumor and antioxidant activity of Polyalthia longifolia stem bark ethanol extract. Pharmaceutical Biology, 48: 690.
Mohanty, C. and Sahoo, S.K. (2010). The in-vitro stability and in-vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation. Biomaterials, 31(25): 6597-6611.
Pooja, D., Tunki, L., Kulhari, H., Reddy, B.B. and Sistla, R. (2015). Optimization of solid lipid nanoparticles prepared by a single emulsification-solvent evaporation method. Data Brief. 6:15- 9. doi: 10.1016/j.dib.2015.11.038.
Priya, R., Ilavenil, S., Kaleeswaran, B., Srigopalram, S. and Ravikumar, S. (2011). Effect of Lawsonia inermis on tumor expression induced by Dalton’s lymphoma ascites in Swiss albino mice. Saudi Journal of Biological Sciences, 18(4): 353-359.
Sakthivel, K.M., Kannan, N., Angeline, A. and Guruvayoorappan, C. (2012). Anticancer activity of Acacia nilotica (L.) Wild. Ex. Delile subsp. indica against Dalton's ascitic lymphoma induced solid and ascitic tumor model. Asian Pacific Journal of Cancer Prevention, 13(8):3989-3995.
Shaikh, J., Ankola, D.D., Beniwal, V., Singh, D. and Kumar, M.R. (2009). Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. European Journal of Pharmaceutical Sciences, 37(3-4):223-230.
Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A. and Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3):209-249.
Downloads
Submitted
Published
Issue
Section
License
All the copy right belongs to the sponsoring Organization, Tamil Nadu Veterinary and Animal Sciences University, Chennai - 51.