THE EFFECTS OF NANOFORMS OF SILIBININ AND RESVERATROL ON THE BODY WEIGHTS, FEED INTAKE, AND WATER INTAKE OF HEPATOCARCINOGENESIS INDUCED RATS
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Authors
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J. Venkatesh Yadav
Ph.D. Scholar, Department of Veterinary Pathology, Madras Veterinary College, Chennai – 600 007
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G. V. Sudhakar Rao
Professor and Head, Department of Veterinary Pathology, Madras Veterinary College, Chennai - 600 007
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N. Pazhanivel
Professor, Department of Veterinary Pathology, Madras Veterinary College, Chennai - 600 007
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G. Sarathchandra
Professor and Head, PLAFFS, DCAHS, Madhavaram Milk Colony, Chennai-600 051
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T.M.A Senthil Kumar
Professor and Head, Zoonosis Research Laboratory, TANUVAS, MMC, Chennai – 600 051
Keywords:
Hepatocellular carcinoma, Resveratrol, Silibinin, Diethyl nitrosamine, RatsAbstract
Hepatocellular carcinoma is one of the most common occurring malignancies in the world and has been reported in various species of
animals including dogs, cats, sheep and pigs. The aim of this study was to assess the ameliorative effects of nanoforms of silibinin and resveratrol on the body weights, feed intake, and water intake of hepatocarcinogenesis induced rats. One hundred and eight male Wistar rats were randomly divided into nine groups and feed intake, water consumption, body weight gains were recorded. The study revealed a significant difference in the feed intake, water intake, body weights in carcinogen group with control and treatment groups.
Nano resveratrol and nano silibinin groups effectively ameliorated compared to raw resveratrol and raw silibinin groups there by suggesting their usage in therapy for liver cancer.
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