ALLEVIATIVE EFFECT OF ETHANOLIC EXTRACT OF Mirabilis jalapa L. ON THE HAEMATO-BIOCHEMICAL PARAMETERS OF HIGH-FAT DIET-INDUCED ATHEROSCLEROSIS IN WISTAR RATS
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Authors
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Priyanka Swami D
PhD Scholar, Department of Veterinary Pathology, MVC, Tamil Nadu Veterinary and Animal Sciences University
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Pazhanivel N
Professor, Department of Veterinary Pathology, MVC, Tamil Nadu Veterinary and Animal Sciences University
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Rao G.V.S
Professor and Head, Department of Veterinary Pathology, MVC, Tamil Nadu Veterinary and Animal Sciences University
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Parthiban M
Professor, Department of Animal Biotechnology, MVC, Tamil Nadu Veterinary and Animal Sciences University
Keywords:
Atherosclerosis, haemato-biochemical parameters, high fat dietAbstract
Atherosclerosis is one of the risk factors for coronary artery disease. The present study was conducted to find out the alleviative effect of ethanolic extract of Mirabilis jalapa L. against haemato-biochemical alterations of high-fat diet-induced atherosclerosis in Wistar rats. Fifty-four Wistar rats (male – 27 and female – 27) were randomly divided into six different groups: Group I (normal pellet feed), group II (high-fat diet), group III (root extract of Mirabilis jalapa L.), group IV (atorvastatin), group V (HFD + root extract of Mirabilis jalapa L.) and group VI (HFD + atorvastatin). The treatments were given from the 8thday to the 30th day in group V and group VI. Haematological parameters, hepatic enzymes, serum lipid profile and atherogenic indices were studied in HFD induced atherosclerosis. Ethanolic extract of M. jalapa L. (EEM) showed a highly significant reduction in lipid profile, atherogenic indices, hepatic enzymes (ALT and AST) compared with the HFD group. No significant differences were observed in the haematological values of all the groups. The results indicated that M. jalapa L. has a partial alleviative effect on HFD induced biochemical changes in the atherosclerotic rat.
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