In vitro anti-Bacterial and Biological properties of magnetron sputtered silver nanoparticles containing titanium implants
Keywords:
Infection, silver nanoparticles, antibacterial effectAbstract
Bacterial infection followed by implant fixation is a common complication after surgery. In order to reduce the incidence of implant-associated infections, several biomaterial surface treatments have been proposed. In this study, the effect of in vitro antibacterial activity of magnetron sputtered silver nanoparticles was studied. Sputtering was done using radiofrequency magnetron sputtering technology. Film applicator coating assay was used to assess the antibacterial effect of the coated titanium implants. SEM examination revealed successful deposition of silver nanoparticles on the titanium surface. The average diameter of the nanoparticles was 40-60 nm. SEM examination before incubation and after incubation of bacteria was done. The bactericidal ratio between the uncoated and coated implant was determined.
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Geetha. M., A. K. Singh, R. Asokamani and A. K. Gogia, 2009. Ti based biomaterials, the ultimate choice for orthopaedic implants – a review. Prog MaterSci., 54(3):397–425.
Esposito. M., J. Hirsch, U, Lekholm and P. Thomsen, 1998. Biological factors contributing to failures of osseointegrated oral implants. (II). Etiopathogenesis. Eur J Oral Sci., 106(3):721–764.
Monteiro. D. R., L. F. Gorup, A. S. Takamiya and A. C. Ruvollo-Filho, E. R. Camargo and Barbosa DB, 2009. The growing importance of materials that prevent microbial adhesion: antimicrobial effect of medical devices containing silver. Int J Antimicrob Agents., 34(2):103–110.
Antoci. V., J. C. S. Adams and J. Parvizi, 2008. The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin modified titaniumalloy and implications for the treatment of periprosthetic infection. Biomaterials.,29(35): 4684–4690.
Vester. H., B. Wildemann and G. Schmidmaier, 2010. Gentamycin delivered from a PDLLA coating of metallic implants: in vivo and in vitro characterisation for local prophylaxis of implant-related osteomyelitis. Injury. , 41(10):1053–1059.
Agarwal. A., T. L. Weis and M. J. Schurr, 2010. Surfaces modified with nanometerthick silver-impregnated polymeric films that kill bacteria but support growth of mammalian cells. Biomaterials. 31(4): 680–690.
Chen. X.,and H. J. Schluesener. Nanosilver: a nanoproduct in medical application. Toxicol Lett., 176(1):1–12.
Cao H., X. Liu and F. Meng, 2011. Biological actions of silver nanoparticles embedded in titanium on antibacterial activity in vitro. Biomaterials., 32(3): 693–705.
Juan, L., Z. Zhimin, M Anchun, L Lie and Z. Jingchae, 2010. Deposition of silver nanoparticles on titanium surface for antibacterial effect. International Journal of Nanomedicine., 5: 261-267.
Zhao, L., H. Wang, K. Huo, L. Cui, W. Zhang, H. Ni, Y. Zhang, Z. Wu and P. K. Chu, 2011. Antibacterial nano-structured titania coating incorporated with silver nanoparticles. J. Biomaterials., 32: 5706-5716.
Goodman, S. B., Z. Yao, M. Keeney and F. Yang, 2013. The future of biologic coatings for orthopaedic implants.J. Biomaterials., 34: 3174-3183.
Jemat, A., M. J. Ghazali, M. Razali and Y. Otsuka, 2015. Surface modifications and their effects on titanium dental implants.J. Biomed. Research International., pp. 1-11.
Lkhagvajav, N., I. Yasa, E. Celik, M. Koizhaiganova and O. Sari, 2011. Antimicrobial activity of colloidal silver nanoparticles prepared by sol-gel method.Digest Journal of Nanomaterials and biostructures., 6: 149-154.
Moseke, C., U. Gbureck, P. Elter, P. Drechsler, A. Zoll, R. Thull and A. Ewald, 2011. Hard implant coatings with antimicrobial properties. J Mater Sci: Mater Med., 11: 4457-4469.
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