APPLICATION OF ACUTE PHASE PROTEINS AS BIOMARKERS IN MODERN VETERINARY PRACTICE
Keywords:
acute phase proteins, biomarker, animal disease diagnosis, Serum amyloid A, C-reactive proteinAbstract
Animal body reacts to all kinds of injuries and stress to keep the homeostasis. Such resistance can be specific or non specific. Non specific innate resistance of the body like cytological and cytokine reactions including fever, leukocytoses etc. are known as acute phase response. In this response, there will be increase or decrease of serum concentration of particular proteins. These proteins are known as acute phase proteins. Measurement of serum concentration of these acute phase proteins are found to be useful in assessment of health status and prediction of diseases of the man and animals. Acute phase proteins like Serum amyloid A, C- reactive proteins, Haptoglobin, alpha 1 acid glycoprotein etc. are found to be more sensitive and specific than the routine diagnostic methods like white blood cell count. Use of acute phase proteins as biomarkers for animal disease diagnosis and health status assessment has got high potential in modern veterinary practice. Usefulness of the acute phase protein analysis in veterinary practice especially in dog, cat, cattle and pig practices is discussed in this review.
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