HISTOMORPHOLOGICAL STUDIES OF ATORVASTATIN TREATMENT IN MOUSE MODEL OF SEPSIS

R. Gohul; T. Ramasamy; S. Hemalatha; S. Ramesh; S. Siva; M. Nivetha; A. Elamaran

doi:10.56093/ijvasr.v54i1.165829

Authors

R. Gohul M.V.Sc. Scholar, Department of Veterinary Pharmacology and Toxicology, Madras Veterinary College, Chennai
T. Ramasamy Assistant Professor, Department of Veterinary Pharmacology and Toxicology, Madras Veterinary College, Chennai
S. Hemalatha Professor, Department of Veterinary Pathology, Madras Veterinary College, Chennai
S. Ramesh Professor and Head, Department of Veterinary Pharmacology and Toxicology, Madras Veterinary College, Chennai
S. Siva M.V.Sc. Scholar, Department of Veterinary Pathology, Madras Veterinary College, Chennai
M. Nivetha M.V.Sc. Scholar, Department of Veterinary Pharmacology and Toxicology, Madras Veterinary College, Chennai
A. Elamaran Ph.D. Scholar, Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Orathanadu

https://doi.org/10.56093/ijvasr.v54i1.165829

Keywords:

Atorvastatin, caecal ligation and puncture, histopathology, mice, multiorgan, sepsis

Abstract

This study aimed to assess the protective effects of atorvastatin in a mouse model of sepsis induced by caecal ligation and puncture (CLP). Eighteen male Swiss albino mice were divided into three groups: sham operation (n=6), CLP alone (n=6) and atorvastatin-treated CLP (n=6). Atorvastatin was administered 18h and 3h prior to CLP induction. After 20 hours of CLP, vital organ tissues (liver, lungs, spleen, kidneys, and brain) were collected for histopathological analysis. The CLP group exhibited severe damage, including congestion, hemorrhage and organ-specific abnormalities. Conversely, the atorvastatin-treated CLP group showed no observable lesions. Histological findings from this study suggested that atorvastatin pretreatment in sepsis prevents cellular damage, modulates inflammatory responses and preserves vascular integrity. The study underscores the potential of atorvastatin as a preventive measure against multiorgan damage in acute sepsis, filling a gap in existing literature on atorvastatin’s role in sepsis prevention.

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