SUCCESSFUL MANAGEMENT OF CENTRAL VESTIBULAR DISEASE WITH PROGESTERONE IN A KANNI DOG – A CASE REPORT
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Keywords:
Kanni dog, central vestibular disease, neuron specific enolase, progesteroneAbstract
A 2-year-old male Kanni dog was presented to the Veterinary College and Research Institute, Orathanadu with a history of head tilt, unable to balance while walking and with suspicion of traumatic brain injury. On clinical examination, neurological signs like compulsive walking, head tilt, circling, nystagmus, staggering gait, decreased proprioception and tactile reflexes were observed. The blood samples were analyzed for hematological and biochemical profile analysis and all parameters were in normal range except mild leukocytosis. The cerebro-spinal fluid was collected and neuron specific enolase (NSE), a neural biomarker was estimated. The CSF was red-tinged and had elevated NSE value (41.42 ng/ml). Based on history, clinical signs and NSE values, the case was diagnosed as central vestibular disease. The animal was treated with polyionic fluids – inj. ringers lactate @ 10ml/kg I/V, inj. hydroxyprogesterone caproate @ 2mg/kg, I/M, inj. cefotaxime @ 25 mg/kg I/V and Inj. B Complex vitamins, I/V. The animal was prescribed with oral micronized progesterone @ 5 mg/kg. On day 7, only mild head tilt and nystagmus were noticed. On day 14 post therapy, the clinical signs were resolved and NSE value became normal.
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References
Boudreau, C.E., Dominguez, C.E., Levine, J.M., Mankin, J., Anderson, K.M., Voges, A.K. and Fosgate, G.T. (2018). Reliability of interpretation of neurologic examination findings for the localization of vestibular dysfunction in dogs. Journal of the American Veterinary Medical Association, 252(7): 830-8.
González, S.L. (2020). Progesterone for the treatment of central nervous system disorders: the many signaling roads for a single molecule. Neural Regeneration Research, 15(10): 1846-7.
Guennoun, R., Labombarda, F., Deniselle, M.G., Liere, P., De Nicola, A.F. and Schumacher, M. (2015). Progesterone and allopregnanolone in the central nervous system: response to injury and implication for neuroprotection. The Journal of steroid biochemistry and molecular biology, 146:48-61.
Jiang, C., Cui, K., Wang, J. and He, Y. (2011). Microglia and cyclooxygenase 2: possible therapeutic targets of progesterone for stroke. International immunopharmacology, 11(11): 1925-31.
Kraus, W.L., Montano, M.M. and Katzenellenbogen, B.S. (1993). Cloning of the rat progesterone receptor gene 5’-region and identification of two functionally distinct promoters. Molecular endocrinology. 7(12):1603-16.
Lahunta, D.A. and Glass, E. (2009).Vestibular system: special proprioception. Veterinary neuroanatomy and clinical neurology. 319.
Lowrie, M and Vetmb, M. (2012). Vestibular disease: anatomy, physiology, and clinical signs. Compendium: Continuing Education for Veterinarians, 34(7):E1.
Marcus, H.J., Paine, H., Sargeant, M., Wolstenholme, S., Collins, K., Marroney, N., Arshad, Q., Tsang, K., Jones, B., Smith, R., and Wilson, M.H. (2019). Vestibular dysfunction in acute traumatic brain injury. Journal of neurology, 266:2430-3.
Nagy, B., Szekeres-Barthó, J., Kovács, G.L., Sulyok, E., Farkas, B., Várnagy, A., Vértes, V., Kovács, K. and Bódis, J. (2021). Key to life: physiological role and clinical implications of progesterone. International Journal of Molecular Sciences, 22(20):11039.
Radulescu, S.M., Humm, K., Eramanis, L.M., Volk, H.A., Church, D.B., Brodbelt, D. and O’Neill, D.G. (2020). Vestibular disease in dogs under UK primary veterinary care: epidemiology and clinical management. Journal of Veterinary Internal Medicine, 34(5):1993-2004.
Rossmeisl, J.H. (2010). Vestibular disease in dogs and cats. Veterinary Clinics: Small Animal Practice, 40(1):81-100.
Stein, D.G., Wright, D.W. and Kellermann, A.L. (2008). Does progesterone have neuroprotective properties? Annals of Emergency Medicine, 51(2):164-72.
Stein, D.G.,(2008). Progesterone exerts neuroprotective effects after brain injury. Brain Research Reviews. 57(2):386-97.
Thomas, W.B. (2000). Vestibular dysfunction. Veterinary Clinics of North America: Small Animal Practice, 30(1):227-49.
Ye, J.N., Chen, X.S., Su, L., Liu, Y.L., Cai, Q.Y., Zhan, X.L., Xu, Y., Zhao, S.F. and Yao, Z.X. (2013). Progesterone alleviates neural behavioral deficits and demyelination with reduced degeneration of oligodendroglial cells in cuprizone-induced mice. PLoS One. 8(1): e54590.
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