Detection of Trypanosoma evansi in the cerebrospinal fluid of a dog exhibiting neurological manifestations

Sirigireddy Sivajothi; Bhavanam Sudhakara Reddy; Gollapalli Nagarjuna

doi:10.56093/ijvm.v44i2.157129

Authors

Sirigireddy Sivajothi
Bhavanam Sudhakara Reddy
Gollapalli Nagarjuna

https://doi.org/10.56093/ijvm.v44i2.157129

Keywords:

Trypanosoma evansi, dog, cerebrospinal fluid, nervous signs

Abstract

A four-year-old Spitz was brought to the clinic with a history of dullness and chronic emaciation. Pale mucous membranes, corneal opacity, hypothermia, irregular heart rate, bounding pulse and poor response to external stimuli were observed. Laboratory tests revealed anaemia, decreased serum albumin, and glucose levels. Trypanosoma evansi organisms were detected in blood smears and cerebrospinal fluid. The cerebrospinal fluid analysis showed an increased cell count, and reduced glucose levels. The dog was treated with diminazene aceturate but unfortunately died on the fifth day of therapy.

Downloads

Download data is not yet available.

References

Baldissera, M.D., Souza, C.F. and Boligon, A.A. (2017) Solving the challenge of the blood–brain barrier to treat infections caused by Trypanosoma evansi: evaluation of nerolidol-loaded nanospheres in mice. Parasitology.144(11):1543-1550.

Defontis, M., Richartz, J., Engelmann, N., Bauer, C., Schwierk, V.M., Büscher, P and Moritz A (2012). Canine Trypanosoma evansi infection introduced into Germany. Vet Clin Pathol. 41(3):369-74.

Howe, S., Da Silva, A.S., Athayde, C.L., Costa, M.M. and Corrêa M.M.B (2011). A New Therapeutic Protocol for Dogs Infected with Trypanosoma evansi. Acta Scientiae Veterinariae. 39(3): 988.

Lampe, R., Foss, K.D., Vitale, S., Hague, D.W and Barger, A.M. (2020) Comparison of cerebellomedullary and lumbar cerebrospinal fluid analysis in dogs with neurological disease. J Vet Intern Med. 34:838–843.

Reddy, B.S., Kumari, K.N., Sivajothi, S. and Rayulu, V.C. (2016) Haemato-biochemical and thyroxin status in Trypanosoma evansi infected dogs. J Parasit Dis, 40: 491-495.

Sivajothi, S., Rayulu, V.C. and Reddy, B.S. (2015) Rapid serodiagnosis of Trypanosoma evansi in dogs by colloidal dye immunobinding assay, Comp Clin Pathol 24 (6): 1497-1500.

Sivajothi, S. and Reddy, B.S. (2016) Polypeptide profiles of diminazene aceturate resistant Trypanosoma evansi organisms isolated from a buffalo. J Veter Sci Med. 4(1): 1.

Sivajothi, S. and Reddy, B.S. (2018) Trypanosoma evansi infection in a cat -a rare case. Comp Clin Pathol, 27: 115-116.