Studies on thyroid dysfunction in dogs using radioimmunoassay
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Authors
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Dadke Anand Rajshekhar
Bombay Veterinary College Near KEM Hospital Besides JBCN School Parel 400 012 Maharashtra India
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Galdhar Chandrakant Narayanrao
Mumbai Veterinary College Parel Mumbai-12
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Gaikwad Rajeev Vasantrao
Mumbai Veterinary College, Parel, Mumbai-12
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Dattatraya Kadam
Mumbai Veterinary College, Parel, Mumbai-12
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Kumarasamy J
Bhabha Atomic Research Center, Mumbai
Keywords:
Thyroid, Radioimmunoassay, TT4, TT3 and fT4Abstract
Fifty-nine clinically healthy dogs, 35 dogs with non-thyroidal illness and 13 suspected clinically hypothyroid dogs were included in the study. Reference ranges were established for thyroid hormone concentrations (TT4, TT3 and fT4) from 59 clinically healthy dogs by RIA. Blood samples were collected from 107 dogs (59 Healthy, 35 Non-thyroidal illness and 13 Hypothyroid) and assessed for thyroid hormone concentration using RIA. Mean (range) values established for TT4, TT3 and fT4 in the present study as 29.67±1.43 nmol/l (11.71-49.26 nmol/l), 1.03±0.02 nmol/l (0.68-1.40 nmol/l) and 9.07±0.52 pmol/l (4.06-18.72 pmol/l) respectively. In geriatric age group thyroid hormone concentration decreased compared to younger dogs. There was non-significant effect of sex on thyroid hormone concentration. TT4 concentration of dogs on homemade diet was lower compared to dogs on commercial and mixed type of diet. Dogs clinically suspected with hypothyroidism had low concentration of thyroid hormone (TT4-18.46±3.20, TT3-0.56±0.07, fT4- 5.68±1.24) as compared to dogs with non-thyroidal illness (TT4-21.78±1.85, TT3-0.85±0.05, fT4-7.80±0.69) and clinically healthy dogs (TT4-29.67±1.43, TT3-1.03±0.02, fT4-9.07±0.52).
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