Antidyslipidemic Effect of Naringenin against 5-Fluorouracil Induced Dyslipidemia in Wistar Rats


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Authors

  • Sravathi Vemula Ph.D Scholar, Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad, Telangana 500030, India
  • Jeevanalatha Mylaram Associate Professor & Head, Department of Veterinary Pathology, College of Veterinary Science, Mamnoor-Warangal, Telangana 500030, India
  • Ravikumar Yadala Assistant Professor & Head, Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad, Telangana 500030, India
  • Gopalareddy Alla Professor, Controller of Examinations, PVNRTVU, Hyderabad, Telangana 500030, India

Keywords:

Triglycerides, lipoprotein, erythrocytes, 5-Fluorocytosine

Abstract

The present study was conducted in forty adult male rats for 5-Fluorouracil (5-FU) chemotherapeutic drugdyslipidemia toxicity and to evaluate ameliorative effects of Naringenin (NG). The rats were randomly divided into four equal groups:  Group 1 (Normal saline), Group 3 (NG) given orally, Group 2 5-FU (20 mg/kg body weight- five days-intraperitoneally), Group 4 received a combination of 5-FU and ameliorative agent for 28 days. Results showed that 5-FU increased heart weights, altered serum lipid profiles and caused noticeable ventricular hypertrophy. However, Group 4 displayed improved serum lipid levels, reduced heart weights due to mitigative action of ameliorative agent.

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Submitted

2023-11-09

Published

2023-11-09

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Section

Articles

How to Cite

Antidyslipidemic Effect of Naringenin against 5-Fluorouracil Induced Dyslipidemia in Wistar Rats. (2023). The Indian Veterinary Journal, 100(11), 27-29. https://epubs.icar.org.in/index.php/IVJ/article/view/145083