Antidyslipidemic Effect of Naringenin against 5-Fluorouracil Induced Dyslipidemia in Wistar Rats
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Authors
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Sravathi Vemula
Ph.D Scholar, Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad, Telangana 500030, India
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Jeevanalatha Mylaram
Associate Professor & Head, Department of Veterinary Pathology, College of Veterinary Science, Mamnoor-Warangal, Telangana 500030, India
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Ravikumar Yadala
Assistant Professor & Head, Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad, Telangana 500030, India
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Gopalareddy Alla
Professor, Controller of Examinations, PVNRTVU, Hyderabad, Telangana 500030, India
Keywords:
Triglycerides, lipoprotein, erythrocytes, 5-FluorocytosineAbstract
The present study was conducted in forty adult male rats for 5-Fluorouracil (5-FU) chemotherapeutic drugdyslipidemia toxicity and to evaluate ameliorative effects of Naringenin (NG). The rats were randomly divided into four equal groups: Group 1 (Normal saline), Group 3 (NG) given orally, Group 2 5-FU (20 mg/kg body weight- five days-intraperitoneally), Group 4 received a combination of 5-FU and ameliorative agent for 28 days. Results showed that 5-FU increased heart weights, altered serum lipid profiles and caused noticeable ventricular hypertrophy. However, Group 4 displayed improved serum lipid levels, reduced heart weights due to mitigative action of ameliorative agent.
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References
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