Evaluation of Isooxazoline derivatives in the Treatment of Canine Demodicosis

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  • Pardeep Sharma Department of Veterinary Medicine, Dr. GC Negi College of Veterinary and Animal Sciences CSK Himachal Pradesh Krishi Vishwavidyalaya Palampur, Himachal Pradesh-176062, India
  • Abhishek Bansal Department of Veterinary Medicine, Dr. GC Negi College of Veterinary and Animal Sciences CSK Himachal Pradesh Krishi Vishwavidyalaya Palampur, Himachal Pradesh-176062, India


afoxolaner, Demodex canis, fluralaner, sarolaner


Canine demodicosis is a common dermatological condition observed indogs. The aim of this study was to evaluate the effectiveness of isooxazoline derivatives for the treatment of demodicosis compared to ivermectin.Forty-one dogs with demodicosis were treated with ivermectin (n=13), fluralaner(n=5), sarolaner(n=11) and afoxolaner (n=12),respectively. The mite count was evaluated on day 0, 28, 56 and 84 of treatment period. A single oral dose of isooxazoline derivatives reduced Demodex mite counts in skin scrapings by an average of 98.6% in all dogs by 28th day and 100% by 84th day. Single administration of ivermectin resulted to be only 76.8% effective. No adverse effects of drugs were observed in any of the dogs.


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Beugnet, F., Halos, L., Larsen, D., and de Vos, C. (2016)Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis. Parasite.23:14.

Chander, R., Choudhary, S., Singh, AP., Kachhawa, J. P., and Saharan, D.K. (2020) Comparative evaluation of different therapy for canine demodicosis. J. Entomol. Zool. Stud.8(3): 1534-1539.

Deepak, D., Chaudhary, A. K., Yadav, S., Das, A. K., Patel, P.K., Paul, B. R., De, U. K. and Dixit, S. K.,(2018) Clinical investigation and therapeutic management of canine demodicosis with doramectin: A case study. J. Entomol. Zool. Stud.6(6): 1012-1015.

Fourie, J. J., Liebenberg, J. E., Horak, I. G., Taenzler, J., Heckeroth, A. R., and Frenais, R. (2015) Efficacy of orally administered Fluralaner (BravectoTM) or topically applied imidacloprid/moxidectin (Advocate®) against generalized demodicosis in dogs. Parasit.Vectors.8(1): 1-7.

Gupta, N., and Prasad, B. (2001) Clinical diagnosis and therapeutic management of Acariasis in dogs. Indian Vet. J.21(2): 73-75.

Kumar, P., and Shekhar,S. (2020) Occurrence of dermatological disorders and Haemato biochemical alteration, treatment of Demodicosis in dogs. J. Entomol. Zool.8: 126-132.

Lebon, W., Beccati, M., Bourdeau, P., Brement, T., Bruet, V., Cekiera, A., Crosaz, O., Darmon, C., Guillot, J., Mosca, M. and Pin, D. (2018) Efficacy of two formulations of Afoxolaner (NexGard® and NexGard Spectra®) for the treatment of generalised demodicosis in dogs, in veterinary dermatology referral centers in EuropeParasit. Vectors.11(1): 1-10.

Nam, H., Yun, T., Koo, Y., Chae, Y., Lee, D., Park, J., Choi, Y., Kim, H., Yang, M. P. and Kang, B. T. (2021) Oral Fluralaner Treatment in a Dog with Desperate Demodicosis: A Case Report. J. Vet. Clin.38(4): 169-173.

Noli, C. (2000) Practical laboratory methods for the diagnosis of dermatologic diseases. In: Bonagura JB (Editor), Current Veterinary Therapy-Small Animal Practice XIII. WB Saunders, Philadelphia, 13: 526-530.

Petersen, I., Chiummo, R., Zschiesche, E., Karas-Tecza, J., Rapti, D., Roepke, R. and Thomas, E. (2020) A European Field Assessment of the efficacy of fluralaner (Bravecto®) chewable and spot-on formulations for treatment of client-owned dogs with generalized demodicosis.Parasit. Vectors.13, 304.

Plumb, D.C.(2005) Veterinary Drug Handbook. 5th edition, Pharma Vet Inc., Wisconsin, pp.: 18-20.

Ramsey, I. K.(Ed.) (2017) BSAVA Small Animal Formulary: Part A, Canine and Feline. 9th edition, British Small Animal Veterinary Association, Gloucester.

Salem, N.Y., Abdel-Saeed, H., Farag, H. S., and Ghandour, R. A. (2020) Canine demodicosis: Hematological and biochemical alterations. Vet. World13(1): 68.

Six, R. H., Becskei, C., Mazaleski, M. M., Fourie, J. J., Mahabir, S. P., Myers, M. R., and Slootmans, N. (2016) Efficacy of Sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectescynotis. Vet. Parasitol.222: 62-66.

Thapa,G., and Sarkar, S. (2018) Occurrence of Canine Skin Disorder and its Hematobiochemical Alterations. Int. J.Curr.Microbiol.Appl. Sci.7(12): 184-195.





How to Cite

Pardeep Sharma, & Abhishek Bansal. (2023). Evaluation of Isooxazoline derivatives in the Treatment of Canine Demodicosis. The Indian Veterinary Journal, 100(12), 25-28. https://epubs.icar.org.in/index.php/IVJ/article/view/146481