The inhibitory effects of Andrographolide, Evodiamine and Cisplatin in Cervical Cancer Cells


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Authors

  • Lavanya, S.K. Department of Medical Research, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Chengalpattu (Dt), Tamil Nadu, India.
  • N. Palanivel Department of Pathology, TANUVAS, Chennai, Tamil Nadu, INDIA
  • Sundaresan, S. Department of Medical Research, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Chengalpattu (Dt), Tamil Nadu, India

Keywords:

Andrographolide; evodiamine; cisplatin; cervical cancer

Abstract

Cervical cancer could be inhibited by supplementing with bioactive molecules that decrease the proliferation and differentiation of cervical cancer cells and promote cell death. Andrographolide is diterpenoid that have strong anticancer properties. EVO has a number of biological activities, including anticancer, and antinociceptive qualities. Cisplatin is extensively used in the treatment of several human ailments and have great therapeutic results. This drug is also used as a pharmaceutical to counteract tumors. Based on these properties, we investigated the anti-proliferative efficiency of andrographolide (andro), evodiamine (evo), and cisplatin (cis) against cervical cancer cells in vitro. This was measured by cytotoxicity assay in human cervical cancer cells, which showed increased activity in andrographolide and evodiamine compared with cisplatin in a dose- and time-dependent manner. As a result, it is concluded that andrographolide, evodiamine, and cisplatin may repress the proliferation of HeLa cells by increasing cell inhibition and reducing cell viability and their activities.

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Submitted

2023-12-15

Published

2023-12-15

How to Cite

Lavanya, S.K., N. Palanivel, & Sundaresan, S. (2023). The inhibitory effects of Andrographolide, Evodiamine and Cisplatin in Cervical Cancer Cells. The Indian Veterinary Journal, 100(12), 44-49. https://epubs.icar.org.in/index.php/IVJ/article/view/146490