Emergence of Quinolone Resistance in E. coli-associated Coliform Mastitis: A Case Report
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Authors
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Hima, K.M.
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A.Janus
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J.Alex
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P.M.Deepa
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R.L.Rathish
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Biju P.Habeeb
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F.A.Lali
Keywords:
Coliform mastitis, Quinolone resistance and mutationAbstract
A four-year-old Holstein Friesian crossbred cow with coliform mastitis showed poor response to enrofloxacin. Escherichia coli isolated from milk was multidrug resistant, with an enrofloxacin MIC >1024 µg/mL and QRDR mutations in gyrA (Ser83Leu and Asp87Asn) and parC (Ser80Ile). Gentamicin therapy resulted in complete recovery.
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References
Abegewi, U.A., S.N.Esemu, R.N.Ndip and L.M.Ndip (2022), Prevalence and risk factors of coliform-associated mastitis and antibiotic resistance of coliforms from lactating dairy cows in North West Cameroon, PLoS One, 17(7): e0268247.
Balakrishnan, S., P.X.Antony, H.K.Mukhopadhyay, R.M.Pillai, J.Thanislass, V.Padmanaban and M.V.Srinivas (2016), Genetic characterization of fluoroquinolone-resistant Escherichia coli associated with bovine mastitis in India, Veterinary World, 9(7): 705.
Bauer, A.W., W.M.Kirby, J.C.Sherris and M.Turck (1966), Antibiotic susceptibility testing by a standardized single disk method, Am. J. Clin. Path., 45(4_ts): 493-96.
Bej, A.K., J.L.Dicesare, L.Haff and R.M.Atlas (1991), Detection of Escherichia coli and Shigella spp. in water by using the polymerase chain reaction and gene probes for uid, Appl. and Environ. Micro., 57(4): 1013-17.
CLSI [Clinical and Laboratory Standards Institute] (2023), Performance Standards for Antimicrobial Susceptibility Testing. (33rd Ed.), Clinical and Laboratory Standards Institute, Wayne, Pennsylvania, United States of America, 402p.
Janus, A., P.M.Deepa, J.Vergis, R.Rajasekhar, B.P.Habeeb, K.C.Bipin and K.Vijayakumar (2024), Unravelling the complex mechanisms of multidrug resistance in bovine mastitis pathogens: Insights into antimicrobial resistance genes, biofilm dynamics, and efflux systems, Microbial Pathogenesis, 195: 106902.
Urban-Chmiel, R., A.Marek, D.Stępień-Pyśniak, K.Wieczorek, M.Dec, A.Nowaczek and J.Osek (2022), Antibiotic resistance in bacteria—A review, Antibiotics, 11(8): 1079.
Quinn, P., B.Markey, M.Carter and G.R.Carter (2013), Clinical Veterinary Microbiology. (2nd Ed). Mosby, St. Louis, 514p.
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- 2026-03-06 (3)
- 2026-03-06 (2)
- 2026-03-02 (1)