Effect of Rhizophora Root Extracts on Wound Healing and Yeast-Induced Pyrexia in Rats

Mathen Mathew; Martin Xavier K.A.; Suseela Mathew; Asha K.K.; Anandan R.; Ashok Kumar K.

doi:10.56093/ft.v49i2.22293

Authors

Mathen Mathew MPEDA, Regional Office, J.P. Road, Bhimavaram
Martin Xavier K.A. Central Institute of Fisheries Technology, P.O. Matsyapuri, Cochin
Suseela Mathew Central Institute of Fisheries Technology, P.O. Matsyapuri, Cochin
Asha K.K. Central Institute of Fisheries Technology, P.O. Matsyapuri, Cochin
Anandan R. Central Institute of Fisheries Technology, P.O. Matsyapuri, Cochin
Ashok Kumar K. Central Institute of Fisheries Technology, P.O. Matsyapuri, Cochin

https://doi.org/10.56093/ft.v49i2.22293

Keywords:

Antipyretic, excision wound, mangroves, Rhizophora mucronata, Rhizophora apiculata

Abstract

Mangrove plants are part of tropical marine ecosystems of coastal regions of Kerala and their parts are widely used as folklore medicines. Root extracts of Rhizophora mucronata and Rhizophora apiculata from Cochin backwater area were screened for antipyretic and wound healing properties. Methanolic aqueous root extracts of R. mucronata and R. apiculata were tested at 460 and 535 mg kg-1 concentrations respectively, in male albino rats. In both cases, bioactivities were compared with that of standard drug and a control group. Among the two species analyzed, maximum activity was observed in the methanolic root extracts of R. apiculata followed by R. mucronata. It is postulated that antipyretic and wound healing effects are caused by inhibition of prostaglandin synthesis and decrease in the cytokine levels. Phytochemical screening of residues revealed the presence of carbohydrates, alkaloids, tannins, flavonoids, saponins and glycosides, which may account for the observed pharmaceutical effects in the Rhizophora species studied.